MED14 Antibody

Datasheet

Code	CSB-PA070279
Size	US$119
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

O60244

Target Names

MED14

Alternative Names

Activator-recruited cofactor 150 kDa component antibody; ARC150 antibody; Cofactor required for Sp1 transcriptional activation subunit 2 antibody; CRSP complex subunit 2 antibody; DRIP150 antibody; EXLM1 antibody; hRGR1 antibody; MED14 antibody; MED14_HUMAN antibody; Mediator complex subunit 14 antibody; Mediator of RNA polymerase II transcription subunit 14 antibody; RGR1 antibody; RGR1 homolog antibody; Thyroid hormone receptor-associated protein complex 170 kDa component antibody; Transcriptional coactivator CRSP150 antibody; Trap170 antibody; Vitamin D3 receptor-interacting protein complex 150 kDa component antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the Internal region of Human CRSP150.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

IHC, IF, ELISA

Recommended Dilution

Application	Recommended Dilution
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:40000

Protocols

Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene References into Functions

Functional analysis implicates TNRC6A, NAT10, MED14, and WDR5 in RNA-mediated transcriptional activation. PMID: 28813667
This results from a dramatically enhanced ability of MED14-containing complexes to associate with Pol II. PMID: 25383669
VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF and MED14 PMID: 23572530
DRIP150 binds to ISGF3 and regulates transcription PMID: 12509459
CRSP2 gene is expressed in the retina and its exact genomic location is on Xp11.4 between DXS1368 and DXS993 PMID: 12825353
Coactivation of ERalpha by DRIP150 in ZR-75 cells is NR box-independent and requires a novel sequence with putative alpha-helical structure. PMID: 15625066
MED14 and MED1 are used by glucocorticoid receptor in a gene-specific manner, providing a mechanism for promoter selectivity by glucocorticoid receptor PMID: 16239257
Coactivator that enhances estrogen receptor alpha- and specificity protein (SP)-1-mediated transactivation in breast cancer cells. PMID: 17306756

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Subcellular Location

Nucleus.

Protein Families

Mediator complex subunit 14 family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 2370

OMIM: 300182

KEGG: hsa:9282

STRING: 9606.ENSP00000323720

UniGene: Hs.407604

Promotions

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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