CTSG Antibody

Code CSB-PA006190ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA006190ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CTSG Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
CATG antibody; CATG_HUMAN antibody; Cathepsin G antibody; Cathepsin G precursor antibody; CathepsinG antibody; CG antibody; Ctsg antibody; CTSG protein antibody; MGC23078 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Cathepsin G protein (21-255AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Cleaves vimentin. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa.
Gene References into Functions
  1. CTSG was increased in peripheral blood mononuclear cells and muscle tissues of dermatomyositis (DM) patients, and CTSG activity was higher in the serum of DM patients PMID: 28797985
  2. CatG can be used as a novel marker to distinguish different NK cell subsets and MARS116 is applicable to determine cell surface CatG activity by flow cytometry. PMID: 27666013
  3. Results provide evidence that cathepsin G (GC) activates IGF-1R by stimulating IGF-1 release from MCF-7 cells, and that IGF-1R activation is required for CG-induced cell aggregation. PMID: 28544544
  4. Cleavage of the alarmins by Human mast cell chymase and human neutrophil cathepsin G suggests a function in regulating excessive inflammation. PMID: 28053237
  5. Data show that lactoferrin (LF) increases the catalytic activity of cathepsin G (CatG) at physiological concentration. PMID: 26986619
  6. CatG is an essential protease for regulating MHC I molecules PMID: 26837514
  7. Patients with certain polymorphisms in the CTSG gene had lower risk for chronic postsurgical pain compared with wild-types. PMID: 26270939
  8. These in vivo data provide, for the first time, compelling evidence of the collateral involvement of cathepsin G, NE, and proteinase 3 in cigarette smoke-induced tissue damage and emphysema PMID: 24929239
  9. expression levels of ELANE and CTSG were determined by quantitative real-time PCR PMID: 25248056
  10. Elastase and cathepsin G are elevated in the plasma of HD patients, originating from primed PMNLs. In these patients, chronic elevation of these enzymes contributes to cleavage of VE-cadherin and possible disruption of endothelial integrity. PMID: 24877096
  11. Cathepsin G is an antimicrobial protein with bacteriocidal activity against S. aureus and N. gonorrhoeae. PMID: 2116408
  12. proteolytic cleavage of PLTP by cathepsin G may enhance the injurious inflammatory responses that occur in COPD PMID: 24532668
  13. Neutrophil cathepsin G is a physiologic modulator of platelet thrombus formation in vivo and has potential as a target for novel anti-thrombotic therapies. PMID: 23940756
  14. demonstrate that cathepsin G (CG), neutrophil elastase (NE), and to a lesser extent proteinase 3 (PR3), degrade endocan PMID: 23454598
  15. A novel HLA-A*0201 restricted peptide derived from cathepsin G is an effective immunotherapeutic target in acute myeloid leukemia. PMID: 23147993
  16. the targeting and suppression of CTSG by AML1-ETO in t(8;21) AML may provide a mechanism for leukemia cells to escape from the intracellular surveillance system by preventing degradation of foreign proteins. PMID: 22641217
  17. NE and CG bind to the surface of cancer cells, presumably to a cell surface receptor, and subsequently undergo clathrin pit-mediated endocytosis. PMID: 22915586
  18. major binding partners of LEKTI were found to be the antimicrobial peptide dermcidin and the serine protease cathepsin G and no kallikreins. PMID: 22588119
  19. Data suggested the notion that CatG plays a critical role in proinsulin processing and is important in the activation process of diabetogenic T cells. PMID: 21850236
  20. potential of HNE and CatG to be used as markers for early detection of infection. Significant differences in HNE and CatG levels in infected and non-infected wound fluids were observed. PMID: 21488974
  21. CatG was found to be dispensable in invariant chain conversion within intact primary human B cells and dendritic cells. PMID: 21543057
  22. distinct catK/C4-S interactions are necessary for the collagenolytic activity of the enzyme. PMID: 21193413
  23. Neutrophil cathepsin G can either facilitate or impede coagulation via effects on thrombin generation. PMID: 20589323
  24. CatG cleaves human leukocyte antigen (HLA)-DR in vitro. Cleavage occurred on the loop between fx1 and fx2 of the membrane-proximal beta2 domain. In vivo, however, the CatG cleavage site is sterically inaccessible or masked by associated molecules. PMID: 20331476
  25. Historical and recent data on CatG expression, distribution, function and involvement in disease will be summarized and discussed, with a focus on its role in antigen presentation and immune-related events. PMID: 19910052
  26. high molecular mass kininogen down-regulates cathepsin G-induced platelet activation by forming a complex with cathepsin G and thus prevents binding of cathepsin G to platelets PMID: 11920276
  27. UVA light stimulates the production of cathepsin G and elastase-like enzymes by dermal fibroblasts: a possible contribution to the remodeling of elastotic areas in sun-damaged skin. PMID: 11928814
  28. up-regulated by the AML1-MTG8 fusion protein, suggesting a role in the granulocytic maturation characteristic of the t(8;21) acute myelogenous leukemia PMID: 11986950
  29. cathepsin G enhances fibrin deposition under flow conditions by elevating the activation state of fibrinogen-adherent platelets rather than by cleaving coagulation factors PMID: 12524437
  30. BPI and cathepsin G are the major antigenic targets of ANCA seen in patients with systemic sclerosis PMID: 12784398
  31. Serine proteinases cathepsin G and neutrophil elastase cooperate for the proteolytic regulation of CD87/urokinase receptor on monocytic cells. PMID: 14688365
  32. role in development of myelodi leukemia with promyelocytic features PMID: 14737102
  33. Cathepsin G initializes and dominates the destruction of intact myelin basic protein (MBP) by B cell-derived lysosomal extracts, degrading immunodominant MBP epitope and eliminating both its binding to HLA-DRB1*1501 and MBP-specific T cell response. PMID: 15100291
  34. neutrophil elastase and cathepsin G are inhibited by PAI-1 mutants PMID: 15131125
  35. Release of cathepsin G from neutrophils specifically down-regulates the responsiveness of neutrophils to C5a, and this effect may play a role in the down-regulation of acute inflammation. PMID: 15140022
  36. down-regulation of CatG in macrophages is advantageous to M. tuberculosis bacilli and possibly is an important mechanism by which M. tuberculosis is able to evade the host immune defenses PMID: 15385470
  37. oxidants generated by myeloperoxidase regulate cathepsin G activity in vivo PMID: 15967795
  38. Neutrophil cathepsin G is the principal protease to produce CCL15 proteolytic products released in the course of hemofiltration of blood from renal insufficiency patients PMID: 16034099
  39. PF-4 acts as an inhibitor of the CTAP-III-processing enzymes cathepsin G and chymase without becoming cleaved itself as a competitive substrate. PMID: 16317101
  40. the monocyte chemotactic activity of cathepsin G may have a role in the pathogenesis of RA synovial inflammation PMID: 16977463
  41. cathepsin g may play a role in the progression to heart failure by activating angiotensin II, leading to detrimental effects on the heart PMID: 17418861
  42. Substrate specificity for cathepsin G is greatly enhanced when an aromatic side chain and a strong positive charge are incorporated in residue P(1). PMID: 17653609
  43. Cathepsin G from neutrophils and monocytes may provide some pro-coagulant effect by activating FVIII. PMID: 18217133
  44. The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase PMID: 18586676
  45. Cathepsin G increases MMP expression in normal human fibroblasts through fibronectin fragmentation, and induces the conversion of proMMP-1 to active MMP-1. PMID: 18835135
  46. Data report that the two subsets of human dendritic cells differ in their cathepsin distribution, and suggest tha Cathepsin G may be of functional importance. PMID: 19036358
  47. MC are immunoreactive to cathepsin-G in human cutaneous mastocytosis, as well as the co-localization of tryptase and cathepsin-G in MC secretory granules. PMID: 19250736
  48. both Cat-G and PAR(4) play key roles in generating and/or amplifying relapses in ulcerative colitis PMID: 19528350
  49. Cathepsin G is one of the mediators responsible for complement-dependent opsonophagocytic killing of Streptococcus pneumoniae by human neutrophils. PMID: 19620298

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Subcellular Location
Cell surface. Membrane; Peripheral membrane protein.
Protein Families
Peptidase S1 family
Database Links

HGNC: 2532

OMIM: 116830

KEGG: hsa:1511

STRING: 9606.ENSP00000216336

UniGene: Hs.421724

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