CYFIP2 Antibody

Code CSB-PA951951
Size US$100
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  • Western Blot analysis of HEPG2 Hela cells using CYFIP2 Polyclonal Antibody diluted at 1:500. Secondary antibody was diluted at 1:20000
  • Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200
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Product Details

Uniprot No.
Target Names
CYFIP2
Alternative Names
CYFIP2 antibody; KIAA1168 antibody; PIR121Cytoplasmic FMR1-interacting protein 2 antibody; p53-inducible protein 121 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from CYFIP2 at AA range: 1171-1220
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB,ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-2000
ELISA 1:10000-20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
Gene References into Functions
  1. Study characterized the functional roles of the two brain-specific phosphorylation sites (S582 and T1067) of CYFIP2 in cultured hippocampal neurons; found that overexpression of the phospho-blocking T1067A mutant significantly decreased the density of stubby spines, but not other types of spines. Study found that T1067 phosphorylation of CYFIP2 could potentially weaken the interaction between CYFIP2 and Nap1. PMID: 28692454
  2. Increased expression of the cytoplasmic FMR1-interacting protein 2 (CYFIP2), a known FMRP interactor, is detected in fragile X syndrome. PMID: 22268788
  3. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. PMID: 17245118
Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome.
Protein Families
CYFIP family
Tissue Specificity
Expressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients with multiple sclerosis (at protein level).
Database Links

HGNC: 13760

OMIM: 606323

KEGG: hsa:26999

STRING: 9606.ENSP00000325817

UniGene: Hs.519702

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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