CYP4B1 Antibody

Code CSB-PA006448GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
CYP4B1
Alternative Names
CP4B1_HUMAN antibody; CYP4B1 antibody; CYPIVB1 antibody; Cytochrome P450 4B1 antibody; Cytochrome P450 family 4 subfamily B polypeptide 1 antibody; Cytochrome P450 subfamily IVB polypeptide 1 antibody; Cytochrome P450-HP antibody; Microsomal monooxygenase antibody; P450HP antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human CYP4B1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene References into Functions
  1. the Ser207 insertion does not rescue the P450 functional activity of human CYP4B1 that has been lost during evolution. PMID: 26355749
  2. A proline residue in the meander region at position 427 in human CYP4B1 and 422 in rabbit CYP4B1 is important for protein stability and rescues the 4-ipomeanol bioactivation. PMID: 25247810
  3. polymorphism in humans: evidence for a non-functional allelic variant PMID: 12142726
  4. CYP4B1 is a senescene-associated gene in normal human oral keratinocytes. PMID: 12837283
  5. Results demostrated an increased risk of bladder cancer associated with the CYP4B1*1/*2 and *2/*2 genotypes. PMID: 18713828

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Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein Families
Cytochrome P450 family
Tissue Specificity
Detected in the liver and lung (at protein level).
Database Links

HGNC: 2644

OMIM: 124075

KEGG: hsa:1580

STRING: 9606.ENSP00000360991

UniGene: Hs.436317

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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