CYTH3 Antibody

Code CSB-PA002833
Size US$100
  • Western Blot analysis of COS7 cells using GRP1 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
Alternative Names
CYTH3 antibody; ARF nucleotide-binding site opener 3 antibody; ARNO3 antibody; ARNO3 protein antibody; CYH3_HUMAN antibody; Cyth3 antibody; Cytohesin-3 antibody; General receptor of phosphoinositides 1 antibody; Grp1 antibody; PH antibody; PH, SEC7 and coiled-coil domain-containing protein 3 antibody; Protein ARNO3 antibody; PSCD3 antibody; SEC7 and coiled-coil domain-containing protein 3 antibody; SEC7 homolog C antibody; Sec7-3 antibody; Sec7c antibody
Raised in
Species Reactivity
Synthesized peptide derived from the C-terminal region of Human GRP1.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization.
Gene References into Functions
  1. Cytohesin-3 was upregulated in hepatocellular carcinoma tissues, correlating with overall survival/relapse-free survival and tumor size/vascular invasion. PMID: 24966920
  2. The PH domains of cytohesin 2/ARNO and cytohesin 3/GRP1 are responsible for the differential effects of these proteins on cell adhesion to fibronectin. PMID: 22454518
  3. incorporation of the E345K charge reversal mutation into the GRP1 PH domain enhances PI(4,5)P(2) affinity 8-fold and yields constitutive plasma membrane targeting in cells PMID: 21932773
  4. GRP1 is a new corepressor for thyroid hormone receptors, which modulates both positive and negative regulation by T3 by decreasing TR-complex formation on thyroid response elements PMID: 15878955
Subcellular Location
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell junction, tight junction.
Tissue Specificity
Almost absent from liver, thymus and peripheral blood lymphocytes.
Database Links

HGNC: 9504

OMIM: 605081

KEGG: hsa:9265

STRING: 9606.ENSP00000297044

UniGene: Hs.487479

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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