Cleaved-KLK8 (V33) Antibody

1. Telbivudine treatment resulted in increased levels of serum KLK8 protein. Furthermore, eGFR increase was associated with body height-adjusted, post-treatment KLK8 levels PMID: 29936485
2. mRNA expression levels of KLK6 and KLK8 in advanced serous ovarian cancer PMID: 27483364
3. elevated KLK8 expression was correlated with the progression of colorectal cancer. PMID: 28142115
4. KLK8 mRNA expression is associated with aggressive tumor characteristics and it can serve as a novel independent biomarker of unfavorable prognosis for BC patients. PMID: 26099606
5. Occurring independently of cyclophilins and of furin that mediate human papillomavirus 16 L2 exposure, KLK8-mediated cleavage of L1 likely facilitated access to L2, located in the capsid lumen, and potentially uncoating. PMID: 25926655
6. It dissects a schizophrenic susceptibility gene, NRG1. PMID: 24614639
7. KLK8 and KLK14 can signal differentially via the PARs to affect tissue function PMID: 22505524
8. KLK8 as a new active serine protease in human stratum corneum and sweat PMID: 20940292
9. The results of this study indicate that most salivary gland tumors show high levels of expression of KLK8. PMID: 20614312
10. The KLK8-T4 alternative splice variant, alone or in combination, may be a new independent marker of unfavorable prognosis in lung cancer. PMID: 20360129
11. Cervical cancer expressed high level of TADG-14. May play important role in invasion and metastasis. Appears only in abundance in tumor tissue and contains secretion signal sequence. Possible diagnostic use or as therapeutic target. PMID: 14749636
12. Expression of hK8 is increased during the development of ovarian cancer and down-regulated during ovarian cancer progression. PMID: 15138549
13. Amino-terminal sequencing of the activated enzyme demonstrated the cleavage of a 9-aa propeptide from the pro-enzyme; substrate specificiy and effect of metal ions and pH is demonstrated PMID: 16800733
14. KLK8 expression confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness. PMID: 17178872
15. analysis of how a mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory PMID: 17487847
16. kallikreins 5, 7, 8, and 10 are abundantly expressed in human OSCC and may be implicated in malignant progression PMID: 19085836
17. The processed end-point enzymes are the same for both type I and type II kallikrein 8, suggesting that the emergence of type II kallikrein 8 in the human brain likely leads to functional modifications of kallikrein 8. PMID: 19125171
18. Combination of KLK2, 3, 13, and 14 and KLK1, 2, 5, 6, 7, 8, 10, 13, and 14 showed very strong discriminatory potential for semen liquefaction and viscosity, respectively. PMID: 19558318

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HGNC: 6369

OMIM: 605644

KEGG: hsa:11202

UniGene: Hs.104570