D2HGDH Antibody

Code CSB-PA843153LA01HU
Size US$299 How to order?
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  • Western Blot
    Positive WB detected in: Mouse spleen tissue, Mouse brain tissue
    All lanes: D2HGDH antibody at 3μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 57, 33, 35 kDa
    Observed band size: 57 kDa

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) D2HGDH Polyclonal antibody
Uniprot No. Q8N465
Target Names D2HGDH
Alternative Names D2HGDH antibody; D2HGDD-2-hydroxyglutarate dehydrogenase antibody; mitochondrial antibody; EC 1.1.99.- antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human D-2-hydroxyglutarate dehydrogenase, mitochondrial protein (14-521AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The D2HGDH Antibody (Product code: CSB-PA843153LA01HU) is Non-conjugated. For D2HGDH Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA843153LB01HU D2HGDH Antibody, HRP conjugated ELISA
FITC CSB-PA843153LC01HU D2HGDH Antibody, FITC conjugated
Biotin CSB-PA843153LD01HU D2HGDH Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.
Gene References into Functions
  1. D2HGDH-GAL3ST2 is more frequently seen in prostate cancer samples, and seems to be enriched in African Americans. PMID: 27322736
  2. D2HGDH elevates alpha-KG levels via IDH2 expression modulation, influencing histone and DNA methylation, and HIF1alpha hydroxylation. D2HGDH mutants found in diffuse large B-cell lymphoma are enzymatically inert. PMID: 26178471
  3. D2HGDH mutation is not associated with glioblastoma. PMID: 21625441
  4. We did not find evidence for mutations in the genes D2HGDH and L2HGDH as an alternative mechanism for raised 2-hydroxyglutarate levels in brain tumours PMID: 20727073
  5. Observational study of gene-disease association. (HuGE Navigator) PMID: 20727073
  6. Two novel pathogenic mutations in D-2-hydroxyglutarate dehydrogenase gene in patient with a mild presentation and asymptomatic siblings with D-2-hydroxyglutaric aciduria with a splice error (IVS4-2A-->G) and a missense mutation (c.1315A-->G;p.Asn439Asp). PMID: 16037974
  7. This enzyme assay will have utility in differentiating patients with 2-hydroxyglutaric aciduria and in assessing the residual activities linked to pathogenic mutations in the D2HGDH gene PMID: 19283509

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Involvement in disease D-2-hydroxyglutaric aciduria 1 (D2HGA1)
Subcellular Location Mitochondrion.
Protein Families FAD-binding oxidoreductase/transferase type 4 family
Database Links

HGNC: 28358

OMIM: 600721

KEGG: hsa:728294

STRING: 9606.ENSP00000315351

UniGene: Hs.516813

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