D2HGDH Antibody

Code CSB-PA006476GA01HU
Size US$685 How to order?
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Product Details

Uniprot No. Q8N465
Target Names D2HGDH
Alternative Names D2HGDH antibody; D2HGDD-2-hydroxyglutarate dehydrogenase antibody; mitochondrial antibody; EC 1.1.99.- antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human D2HGDH
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.
Gene References into Functions
  1. D2HGDH-GAL3ST2 is more frequently seen in prostate cancer samples, and seems to be enriched in African Americans. PMID: 27322736
  2. D2HGDH elevates alpha-KG levels via IDH2 expression modulation, influencing histone and DNA methylation, and HIF1alpha hydroxylation. D2HGDH mutants found in diffuse large B-cell lymphoma are enzymatically inert. PMID: 26178471
  3. D2HGDH mutation is not associated with glioblastoma. PMID: 21625441
  4. We did not find evidence for mutations in the genes D2HGDH and L2HGDH as an alternative mechanism for raised 2-hydroxyglutarate levels in brain tumours PMID: 20727073
  5. Observational study of gene-disease association. (HuGE Navigator) PMID: 20727073
  6. Two novel pathogenic mutations in D-2-hydroxyglutarate dehydrogenase gene in patient with a mild presentation and asymptomatic siblings with D-2-hydroxyglutaric aciduria with a splice error (IVS4-2A-->G) and a missense mutation (c.1315A-->G;p.Asn439Asp). PMID: 16037974
  7. This enzyme assay will have utility in differentiating patients with 2-hydroxyglutaric aciduria and in assessing the residual activities linked to pathogenic mutations in the D2HGDH gene PMID: 19283509

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Involvement in disease D-2-hydroxyglutaric aciduria 1 (D2HGA1)
Subcellular Location Mitochondrion.
Protein Families FAD-binding oxidoreductase/transferase type 4 family
Database Links

HGNC: 28358

OMIM: 600721

KEGG: hsa:728294

STRING: 9606.ENSP00000315351

UniGene: Hs.516813

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