DAK Antibody

Code CSB-PA184114
Size US$297
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  • Western blot analysis of extracts from K562 cells and A549 cells, using DAK antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TKFC Polyclonal antibody
Uniprot No.
Target Names
TKFC
Alternative Names
ATP dependent dihydroxyacetone kinase antibody; Bifunctional ATP dependent dihydroxyacetone kinase/FAD AMP lyase (cyclizing) antibody; DAK antibody; DHA kinase antibody; Dha kinase/FMN cyclase antibody; DHAK_HUMAN antibody; Dihydroxyacetone kinase antibody; Dihydroxyacetone kinase 2 antibody; Dihydroxyacetone kinase 2 homolog (S. cerevisiae) antibody; Dihydroxyacetone kinase 2 homolog (yeast) antibody; FAD AMP lyase (cyclic FMN forming) antibody; FAD AMP lyase (cyclizing) antibody; FAD-AMP lyase (cyclic FMN forming) antibody; FAD-AMP lyase (cyclizing) antibody; FMN cyclase antibody; Glycerone kinase antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from internal of Human DAK.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response.
Gene References into Functions
  1. The peptide fragment (m/z 520.3) of DAK is a promising biomarker to guide timing of antiviral treatment and to avoid liver biopsy in compensated chronic hepatitis B patients. PMID: 24289155
  2. analysis of human triokinase/FMN cyclase reveals that kinase activity requires intact homodimers, but cyclase requires only a truncated, single domain subunit PMID: 24569995
  3. Evidence supports that a single protein sustains both FMN cyclase and ATP-dependent Dha kinase activities, probably in a single active center PMID: 16289032
  4. DAK, the physiological suppressor of cytoplasmic viral RNA sensor MDA5, specifically inhibits MDA5- but not RNA helicase RIG-I-mediated innate antiviral signaling. PMID: 17600090
Protein Families
Dihydroxyacetone kinase (DAK) family
Tissue Specificity
Detected in erythrocytes (at protein level).
Database Links

HGNC: 24552

OMIM: 615844

KEGG: hsa:26007

STRING: 9606.ENSP00000378360

UniGene: Hs.6278

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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