DCP2 Antibody

Datasheet

Code	CSB-PA810265ESR1HU
Size	US$166
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Image	Western blot All lanes: m7GpppN-mRNA hydrolase antibody at 7μg/ml Lane 1: Hela whole cell lysate Lane 2: Jurkat whole cell lysate Lane 3: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 49, 45 kDa Observed band size: 49 kDa Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA810265ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA810265ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DCP2 Polyclonal antibody

Uniprot No.

Q8IU60

Target Names

DCP2

Alternative Names

DCP2 antibody; DCP2 decapping enzyme homolog (S. cerevisiae) antibody; DCP2, S. cerevisiae, homolog of antibody; DCP2_HUMAN antibody; decapping enzyme 2, S. cerevisiae, homolog of antibody; decapping enzyme homolog (S. cerevisiae) antibody; FLJ33245 antibody; hDpc antibody; m7GpppN-mRNA hydrolase antibody; mRNA decapping enzyme 2 antibody; mRNA-decapping enzyme 2 antibody; Nucleoside diphosphate-linked moiety X motif 20 antibody; nudix (nucleoside diphosphate linked moiety X)-type motif 20 antibody; Nudix motif 20 antibody; NUDT20 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human m7GpppN-mRNA hydrolase protein (1-240AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.

Gene References into Functions

Human Dcp2 levels and activity are controlled by a competition between decapping complex assembly and Dcp2 degradation. PMID: 25870104
Data show that Y14 interacts directly with the decapping factor Dcp2 and the 5' cap structure of mRNAs via different but overlapping domains. PMID: 23115303
an mRNA decapping enzyme demonstrated to contain intrinsic decapping activity PMID: 12218187
Human Dcp2 is a catalytically active mRNA decapping enzyme that localizes to the cytoplasm PMID: 12486012
hDcp2 can specifically bind to and can regulate the stability of a subset of mRNAs PMID: 18039849
These data support the novel notion of the association between Ro52 with hDCP2 protein in cytoplasmic p-bodies, playing a role in mRNA metabolism in response to cellular stimulation. PMID: 18361920

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Subcellular Location

Cytoplasm, P-body. Nucleus.

Protein Families

Nudix hydrolase family, DCP2 subfamily

Tissue Specificity

Expressed in brain and testis. Not detected in heart (at protein level).

Database Links

HGNC: 24452

OMIM: 609844

KEGG: hsa:167227

STRING: 9606.ENSP00000373715

UniGene: Hs.443875

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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