DCXR Antibody

1. Ureaplasma urealyticum infection may affect the level of P34H protein expression on spermatozoa PMID: 28012250
2. identification of DCXR as an enzyme activity mediating chemical redox cycling suggests that it may be important in generating cytotoxic reactive oxygen species in the lung PMID: 28595002
3. Low expression of DCXR is associated with hepatocellular carcinoma. PMID: 27658779
4. EGCG is a potential inhibitor to human DCXR. PMID: 23661708
5. combined frequency of the two mutant DCXR alleles in 1,067 Ashkenazi Jewish controls was 0.0173, suggesting a pentosuria frequency of approximately one in 3,300 in this population PMID: 22042873
6. highly expressed in kidney and liver PMID: 11882650
7. crystallization and preliminary crystallographic analysis PMID: 12136162
8. structure of the tetrameric form of human L-Xylulose reductase PMID: 15906319
9. Our results demonstrate that the proportion of positive P34H cases that produced embryos in vitro clearly differs from cases with undetectable levels of P34H (P<.001). PMID: 16616743
10. These results suggested that altered HCR2 expression might play roles in the carcinogenesis and progression of hepatocellular carcinoma. PMID: 16847567
11. A significant proportion of men investigated for male infertility may be epididymal protein P34H deficient. PMID: 17434498
12. Decreased membranous expression of DCXR with altered subcellular localization appears to be associated with malignant progression of melanocytic lesions in human skin. PMID: 17576332
13. DCXR trranfected into mice may function in the removal of renal alpha-dicarbonyl compounds under oxidative circumstances, but it is not sufficient to suppress acute renal fibrosis. PMID: 18079483
14. DCXR overexpression has the potential to be an additional useful biomarker for prostate cancer. PMID: 18086765
15. The action of human XR may be regulated by cellular redox conditions through reversible disulfide-bond formation and by S-cysteinylation. PMID: 19337691

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HGNC: 18985

OMIM: 260800

KEGG: hsa:51181

STRING: 9606.ENSP00000303356

UniGene: Hs.9857