Product Details

Uniprot No.

Target Names

DCXR

Alternative Names

Carbonyl reductase 2 antibody; Carbonyl reductase II antibody; DCR antibody; Dcxr antibody; DCXR_HUMAN antibody; Dicarbonyl and L xylulose reductase antibody; Dicarbonyl L xylulose reductase antibody; Dicarbonyl/ L xylulose reductase antibody; Dicarbonyl/L-xylulose reductase antibody; HCR2 antibody; HCRII antibody; Human carbonyl reductase 2 antibody; kiDCR antibody; Kidney dicarbonyl reductase antibody; L xylulose reductase antibody; L-xylulose reductase antibody; P34H antibody; PNTSU antibody; SDR20C1 antibody; Short chain dehydrogenase/reductase family 20C member 1 antibody; Sperm surface protein P34H antibody; XR antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human DCXR

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

Gene References into Functions

Ureaplasma urealyticum infection may affect the level of P34H protein expression on spermatozoa PMID: 28012250
identification of DCXR as an enzyme activity mediating chemical redox cycling suggests that it may be important in generating cytotoxic reactive oxygen species in the lung PMID: 28595002
Low expression of DCXR is associated with hepatocellular carcinoma. PMID: 27658779
EGCG is a potential inhibitor to human DCXR. PMID: 23661708
combined frequency of the two mutant DCXR alleles in 1,067 Ashkenazi Jewish controls was 0.0173, suggesting a pentosuria frequency of approximately one in 3,300 in this population PMID: 22042873
highly expressed in kidney and liver PMID: 11882650
crystallization and preliminary crystallographic analysis PMID: 12136162
structure of the tetrameric form of human L-Xylulose reductase PMID: 15906319
Our results demonstrate that the proportion of positive P34H cases that produced embryos in vitro clearly differs from cases with undetectable levels of P34H (P<.001). PMID: 16616743
These results suggested that altered HCR2 expression might play roles in the carcinogenesis and progression of hepatocellular carcinoma. PMID: 16847567
A significant proportion of men investigated for male infertility may be epididymal protein P34H deficient. PMID: 17434498
Decreased membranous expression of DCXR with altered subcellular localization appears to be associated with malignant progression of melanocytic lesions in human skin. PMID: 17576332
DCXR trranfected into mice may function in the removal of renal alpha-dicarbonyl compounds under oxidative circumstances, but it is not sufficient to suppress acute renal fibrosis. PMID: 18079483
DCXR overexpression has the potential to be an additional useful biomarker for prostate cancer. PMID: 18086765
The action of human XR may be regulated by cellular redox conditions through reversible disulfide-bond formation and by S-cysteinylation. PMID: 19337691

Hide All

Involvement in disease

Pentosuria (PNTSU)

Subcellular Location

Membrane; Peripheral membrane protein.

Protein Families

Short-chain dehydrogenases/reductases (SDR) family

Tissue Specificity

Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.

Database Links

HGNC: 18985

OMIM: 260800

KEGG: hsa:51181

STRING: 9606.ENSP00000303356

UniGene: Hs.9857

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Code	CSB-PA006577GA01HU
Size	$600
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DCXR Antibody

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Target Background