DEFA6 Antibody

Code CSB-PA980801GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
alpha 6 antibody; DEF6 antibody; DEF6_HUMAN antibody; DEFA 6 antibody; DEFA6 antibody; Defensin 6 antibody; Defensin alpha 6 antibody; Defensin alpha 6 Paneth cell specific antibody; Defensin antibody; Defensin-6 antibody; HD 6 antibody; HD6 antibody
Raised in
Species Reactivity
Fusion protein of Human DEFA6
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen affinity purification
It differs from different batches. Please contact us to confirm it.
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Tested Applications
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.
Gene References into Functions
  1. HD6 assembled into nanonets can prevent key steps in C. albicans pathogenesis PMID: 28198610
  2. alpha-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans PMID: 28026958
  3. Downregulation of HD6 in noninflamed mucosa may contribute to mucosal barrier dysfunction of patients with Crohn's Disease. PMID: 26891258
  4. Paneth cell alpha-defensin 6 is an antimicrobial peptide. PMID: 25354318
  5. Native HD-6 readily self-assembles into elongated fibrils observable by transmission electron microscopy, agglutinates both Gram-negative and -positive bacteria, and prevents the Listeria monocytogenes from invading cultured cells. PMID: 25158166
  6. In the meta-analysis, DEFA6 rs13275170 and DEFB1 rs2738169 had both a 1.3-fold increased odds ratio for gastric cancer. PMID: 23028900
  7. study reports that HD6 affords protection against invasion by enteric bacterial pathogens in vitro and in vivo; after stochastic binding to bacterial surface proteins, HD6 undergoes ordered self-assembly to form fibrils and nanonets that surround and entangle bacteria PMID: 22722251
  8. Regions 2, 3 & 9, 10 were more hydrophobic than other regions. It was difficult for the HD molecule to have many conformations because of its 3 S-S bridges; however, it responds to various external factors by restricting conformation. PMID: 21873175
  9. Defensin alpha 6 (DEFA 6) may have a role in adenoma but not in progression to colon carcinoma PMID: 20979654
  10. defensin alpha6 is highly expressed in colon cancer cell lines PMID: 15613481
  11. Crystal structure of HD6. PMID: 17088326
  12. Human enteric defensin (HD)-5 and HD-6 were detected in Paneth cells, which are observed in the gastric metaplastic mucosa as well as small intestinal epithelia. PMID: 19250512

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Subcellular Location
Protein Families
Alpha-defensin family
Tissue Specificity
Paneth cells of the small intestine.
Database Links

HGNC: 2765

OMIM: 600471

KEGG: hsa:1671

STRING: 9606.ENSP00000297436

UniGene: Hs.711

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