DEFA6 Antibody

Code CSB-PA980801GA01HU
Size $600
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Product Details

Uniprot No. Q01524
Target Names DEFA6
Alternative Names
alpha 6 antibody; DEF6 antibody; DEF6_HUMAN antibody; DEFA 6 antibody; DEFA6 antibody; Defensin 6 antibody; Defensin alpha 6 antibody; Defensin alpha 6 Paneth cell specific antibody; Defensin antibody; Defensin-6 antibody; HD 6 antibody; HD6 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Fusion protein of Human DEFA6
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.
Gene References into Functions
  1. HD6 assembled into nanonets can prevent key steps in C. albicans pathogenesis PMID: 28198610
  2. alpha-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans PMID: 28026958
  3. Downregulation of HD6 in noninflamed mucosa may contribute to mucosal barrier dysfunction of patients with Crohn's Disease. PMID: 26891258
  4. Paneth cell alpha-defensin 6 is an antimicrobial peptide. PMID: 25354318
  5. Native HD-6 readily self-assembles into elongated fibrils observable by transmission electron microscopy, agglutinates both Gram-negative and -positive bacteria, and prevents the Listeria monocytogenes from invading cultured cells. PMID: 25158166
  6. In the meta-analysis, DEFA6 rs13275170 and DEFB1 rs2738169 had both a 1.3-fold increased odds ratio for gastric cancer. PMID: 23028900
  7. study reports that HD6 affords protection against invasion by enteric bacterial pathogens in vitro and in vivo; after stochastic binding to bacterial surface proteins, HD6 undergoes ordered self-assembly to form fibrils and nanonets that surround and entangle bacteria PMID: 22722251
  8. Regions 2, 3 & 9, 10 were more hydrophobic than other regions. It was difficult for the HD molecule to have many conformations because of its 3 S-S bridges; however, it responds to various external factors by restricting conformation. PMID: 21873175
  9. Defensin alpha 6 (DEFA 6) may have a role in adenoma but not in progression to colon carcinoma PMID: 20979654
  10. defensin alpha6 is highly expressed in colon cancer cell lines PMID: 15613481
  11. Crystal structure of HD6. PMID: 17088326
  12. Human enteric defensin (HD)-5 and HD-6 were detected in Paneth cells, which are observed in the gastric metaplastic mucosa as well as small intestinal epithelia. PMID: 19250512

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Subcellular Location Secreted.
Protein Families Alpha-defensin family
Tissue Specificity Paneth cells of the small intestine.
Database Links

HGNC: 2765

OMIM: 600471

KEGG: hsa:1671

STRING: 9606.ENSP00000297436

UniGene: Hs.711

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