DEFA6 Antibody

1. HD6 assembled into nanonets can prevent key steps in C. albicans pathogenesis PMID: 28198610
2. alpha-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans PMID: 28026958
3. Downregulation of HD6 in noninflamed mucosa may contribute to mucosal barrier dysfunction of patients with Crohn's Disease. PMID: 26891258
4. Paneth cell alpha-defensin 6 is an antimicrobial peptide. PMID: 25354318
5. Native HD-6 readily self-assembles into elongated fibrils observable by transmission electron microscopy, agglutinates both Gram-negative and -positive bacteria, and prevents the Listeria monocytogenes from invading cultured cells. PMID: 25158166
6. In the meta-analysis, DEFA6 rs13275170 and DEFB1 rs2738169 had both a 1.3-fold increased odds ratio for gastric cancer. PMID: 23028900
7. study reports that HD6 affords protection against invasion by enteric bacterial pathogens in vitro and in vivo; after stochastic binding to bacterial surface proteins, HD6 undergoes ordered self-assembly to form fibrils and nanonets that surround and entangle bacteria PMID: 22722251
8. Regions 2, 3 & 9, 10 were more hydrophobic than other regions. It was difficult for the HD molecule to have many conformations because of its 3 S-S bridges; however, it responds to various external factors by restricting conformation. PMID: 21873175
9. Defensin alpha 6 (DEFA 6) may have a role in adenoma but not in progression to colon carcinoma PMID: 20979654
10. defensin alpha6 is highly expressed in colon cancer cell lines PMID: 15613481
11. Crystal structure of HD6. PMID: 17088326
12. Human enteric defensin (HD)-5 and HD-6 were detected in Paneth cells, which are observed in the gastric metaplastic mucosa as well as small intestinal epithelia. PMID: 19250512

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HGNC: 2765

OMIM: 600471

KEGG: hsa:1671

STRING: 9606.ENSP00000297436

UniGene: Hs.711