DGKG Antibody

Code CSB-PA006836LA01HU
Size US$166
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  • Western blot
    All lanes: DGKG antibody at 4µg/ml + Mouse brain tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 90, 87, 85 kDa
    Observed band size: 90 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DGKG Polyclonal antibody
Uniprot No.
Target Names
DGKG
Alternative Names
DGKG antibody; DAGK3Diacylglycerol kinase gamma antibody; DAG kinase gamma antibody; EC 2.7.1.107 antibody; Diglyceride kinase gamma antibody; DGK-gamma antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Diacylglycerol kinase gamma protein (1-255AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The DGKG Antibody (Product code: CSB-PA006836LA01HU) is Non-conjugated. For DGKG Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA006836LB01HU DGKG Antibody, HRP conjugated ELISA
FITC CSB-PA006836LC01HU DGKG Antibody, FITC conjugated
Biotin CSB-PA006836LD01HU DGKG Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

To produce the polyclonal antibody that targets DGKG, rabbits were immunized with the recombinant human DGKG protein (1-255aa). Afterward, this DGKG polyclonal antibody was purified using protein G affinity chromatography, resulting in a purity level exceeding 95%. It can recognize and bind to DGKG protein present in human and mouse samples.

This DGKG polyclonal antibody has undergone rigorous validation and is appropriate for use in ELISA and WB. As such, it can be utilized to assess DGKG protein levels and detect its presence and size in different experimental contexts.

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Target Background

Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Has no apparent specificity with regard to the acyl compositions of diacylglycerol. Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination.
Gene References into Functions
  1. Epigenetic silencing of DGKG expression is associated with skin cancer. PMID: 28218473
  2. these results indicate that DGKG is an anionic phospholipid binding protein that preferably interacts with a small highly charged head group that is very close to the glycerol or sphingosine backbone. PMID: 24486543
  3. diacylglycerol kinase gamma regulates macrophage differentiation. PMID: 12732202
  4. the interaction of diacylglycerol kinase gamma with the Src homology 2 and C1 domains of beta2-chimaerin is induced synergistically by Phorbol ester and hydrogen peroxide PMID: 17803461
Subcellular Location
Membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton.
Protein Families
Eukaryotic diacylglycerol kinase family
Tissue Specificity
Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma.
Database Links

HGNC: 2853

OMIM: 601854

KEGG: hsa:1608

STRING: 9606.ENSP00000265022

UniGene: Hs.683449

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