DGKZ Antibody

1. Results show that DGKzeta is downregulated in bone marrow mononuclear cells and associated with the severity of aplastic anemia (AA). Also, DGKzeta is a downstream target gene of miR34a. Their dysregulation enhances T-cell activation in AA cells. PMID: 28008152
2. These results established the positive correlation between DGKzeta expression and gliomagrade. PMID: 26452358
3. these data suggest that the activation of DGKzeta downstream of antigen recognition provides a mechanism that ensures the activation of PA-dependent signaling as a direct result of the strength of TCR-dependent DAG mobilization. PMID: 27999176
4. Diacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review) PMID: 27697466
5. DGKzeta knockdown engenders enhancement of NF-kappaB pathway in response to TNF-alpha. [review] PMID: 26521214
6. Redundant and specialized roles for diacylglycerol kinases alpha and zeta in the control of T cell functions. PMID: 25921290
7. This study shows that DGKzeta knockdown facilitates degradation of IkappaB, followed by nuclear translocation of NF-kappaB p65 subunit. PMID: 25450975
8. Elevated DGKzeta expression contributes to increased Rho GTPase activation and the enhanced motility of metastatic cancer cells. PMID: 24646293
9. Data indicate that after P2Y6 receptor stimulation both phospholipase D (PLD) and DGKzeta enzymes are responsible for producing phosphatidic acid (PA). PMID: 23723068
10. DGK-zeta translocated rapidly to the plasma membrane at early stages of immunological synapse (IS) formation independent of enzyme activity; study highlights a DGKzeta-specific function for local diacylglycerol metabolism at the IS and offers new clues to its mode of regulation PMID: 21937721
11. Antigen-specific CD8-positive T cells from DGKzeta-deficient transgenic mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK-deficient memory CD8+ T cells exhibit impaired expansion. PMID: 22271650
12. Nucleosome assembly protein (NAP) 1-like 1 (NAP1L1) and NAP1-like 4 (NAP1L4) are identified as novel DGKzeta binding partners. PMID: 21996351
13. Data show that Diacylglycerol that 2-arachidonoyl glycerol is a very poor substrate for either the epsilon or the zeta isoforms of diacylglycerol kinases. PMID: 21194521
14. structural domain requirements for translocation and activity PMID: 12015310
15. PKC alpha phosphorylates diacylglycerol kinase zeta in cells, and this phosphorylation inhibits its kinase activity to remove cellular diacylglycerol, thereby affecting cell growth. PMID: 12890670
16. role in controlling the induction of luteinizing hormone beta transcription by ERK1/2 PMID: 14707140
17. DGKzeta generating PA, stimulates PIP5KIalpha activity to increase local PIP2, which regulates actin polymerization. PMID: 15157668
18. DGKzeta-derived phosphatidic acid acts as a mediator of mTOR signaling PMID: 15632115
19. DGKzeta may act in vivo as a downstream effector of pRB to regulate nuclear levels of diacylglycerol and phosphatidic acid PMID: 16286473
20. 2,3-dioleoylglycerol binds to a site on the alpha and zeta isoforms of diacylglycerol kinase that is exposed as a consequence of the substrate binding to the active site. PMID: 18004883
21. PKD activation is induced by DGKzeta, suggesting DGK is an upstream regulator of oxidative stress-induced activation of the PKD signaling pathway in intestinal epithelial cells. PMID: 18694729
22. In DGKzeta-deficient fibroblasts PAK1 phosphorylation and Rac1-RhoGDI dissociation were attenuated, leading to reduced Rac1 activation after platelet-derived growth factor stimulation. PMID: 19211846
23. None of SNPs of diacylglycerol kinase zeta tested showed association with bipolar disorder in Sardinian sample. PMID: 19308020
24. Negative regulation of T cell receptor induced activation of the Ras-Erk1/2-AP1 pathway by DGKz PMID: 12070163

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HGNC: 2857

OMIM: 601441

KEGG: hsa:8525

STRING: 9606.ENSP00000412178

UniGene: Hs.502461