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Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
Gene References into Functions
The crucial role of the insulin/STAT3/DHCR24/PGR axis in the progression of endometrial carcinoma. PMID: 28112250
DHCR24 might be a therapeutic target for patients with bladder cancer PMID: 30278482
Mutation in DHCR24 gene cause desmosterolosis presenting with multiple congenital anomalies with increased level of the cholesterol precursor desmosterol while disrupting development of cholesterol, impacting embryogenesis. PMID: 29175559
Study observed decreased methylation at the DHCR24 locus in offspring of women with active pregnancy eating disorders (ED) and increased methylation at the LGALS2 locus in offspring of women with past ED compared to controls. PMID: 29093763
the expanding database of post-translational modifications will be a valuable resource for mapping the topology of membrane-associated proteins, such as DHCR24, that is, flagging cytosolic residues accessible to modifying enzymes such as kinases and ubiquitin ligases. PMID: 27919032
DHCR24 auto-antibody represents a potential noninvasive biomarker for hepatitis C virus-related liver disease and may facilitate the diagnosis of PIVKA-II and AFP-negative hepatocellular carcinoma. PMID: 26288822
In vitro experiments showed that DHCR24 overexpression induced tumor proliferation. PMID: 24562935
Data (including data from studies using RNA from post-mortem brain tissue) suggest that expression of DHCR24 is up-regulated in parietal cortex of patients with Huntington's disease as compared to control subjects. PMID: 24916565
Data indicate a mechanism whereby 3beta-hydroxysterol Delta24-reductase (DHCR24) activity is regulated by signaling. PMID: 24363437
DHCR24 expression protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum stress. PMID: 24489783
TR-beta and LXR-alpha competitively up-regulate the human Seladin-1 promoter, sharing the same response element, site A. PMID: 23416078
DHCR24 gene expression is regulation by cholesterol availability. PMID: 23050906
Inflammation is inhibited in coronary artery endothlial cells by increasing 3beta-hydroxysteroid-Delta24 reductase expression. PMID: 23123430
a novel role for 24,25EC in cholesterol homeostasis, through its rapid inhibition of cholesterol synthesis at DHCR24. PMID: 22178193
a gender dependent effect of DHCR24 rs600491 polymorphism on the susceptibility to Alzheimer disease. PMID: 22910610
Activation of Sp1 by oxidative stress is involved in the promotion of expression of DHCR24 by Hepatitis C virus. PMID: 22431021
This study describes Simvastatin modulates the Alzheimer's disease-related gene seladin-1. PMID: 21987590
DHCR24-overexpressed cells were protected from apoptosis in response to oxidative stress, which was accompanied by a decrease in DHCR24 content on the ER and activation of caspase-3. PMID: 22010141
affected individuals have a homozygous missense mutation in DHCR24 leading to dramatically augmented plasma desmosterol levels. We thus establish a clear consistent phenotype of desmosterolosis (MIM 602398). PMID: 21559050
Level of brain amyloid deposition on [(11)C]PiB PET was associated with rs7551288, an intronic SNP in DHCR24, in 103 participants. The minor allele was associated with lower PiB uptake with non-carriers showing higher PiB uptake in frontal regions. PMID: 21901424
DNA methylation and histone acetylation have roles in regulating the promoter region of the human DHCR24 gene PMID: 20568014
Promoter methylation could be involved in the altered pattern of seladin-1 gene expression in adrenal carcinoma. PMID: 20465827
Reduced expression of the enzyme that converts desmosterol into cholesterol, Alzheimer indicator 1 gene (seladin-1/dhcr24), in cortex and cerebellum may underlie increased desmosterol levels in 21 month-old amyloid-beta mutant mice. PMID: 20061631
Seladin-1 involvement in proliferation and secretion suggests that its downregulation may be a major mechanism causing prostate cancer evolution. PMID: 20166102
seladin-1/DHCR24 is modulated by the ACTH/cAMP-driven pathway and its expression is reduced in adrenal cancer PMID: 15001630
unanticipated role for Seladin-1, previously implicated in Alzheimer's disease and cholesterol metabolism, in integrating cellular response to oncogenic and oxidative stress PMID: 15577914
High levels of DHCR24 gene expression is associated with melanoma metastases PMID: 15688385
seladin-1 has been isolated and found to be down-regulated in brain regions affected by Alzheimer disease--REVIEW PMID: 15954227
These original results demonstrate for the first time that seladin-1 is abundantly expressed by stem cells and appear to suggest that reduced expression in AD might be due to an altered pool of multipotent cells. PMID: 16762343
DHCR24 gene may be associated with Alzheimer's disease risk. PMID: 17510943
Preliminary results suggest the absence of an association between DHCR24/seladin-1 genotypes and Alzheimer's disease in the Italian population. PMID: 17579359
ablation of DHCR24/seladin-1 prevented apoptosis of primary neurons in a p53-dependent manner PMID: 17984220
DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content. PMID: 18194465
Seladin-1 may be considered a fundamental mediator of the neuroprotective effects of estrogen. PMID: 18499757
the seladin-1 gene is androgen regulated and has a higher level of expression in prostate cancer tissues compared to the normal prostate PMID: 18762779
Seladin-1/DHCR24 is an LXR target gene and that LXR may regulate lipid raft formation. PMID: 18815215
Results suggest that antiinflammatory effects of HDLs are mediated partly through an upregulation of DHCR24. PMID: 19325144
seladin-1 expression and intracellular localization are correlated with both the intensity and nature of ACTH-induced steroidogenesis and resultant oxidative stress. PMID: 19520779
seladin-1 downregulation increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis PMID: 19815556
DHCR24 is elevated in response to HCV infection and inhibits the p53 stress response by stimulating the accumulation of the MDM2-p53 complex in the cytoplasm and by inhibiting the acetylation of p53 in the nucleus. PMID: 19861417
FAD-binding oxidoreductase/transferase type 4 family
Tissue Specificity
Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substan