Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
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3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. Plays also a role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH.
Gene References into Functions
The study findings suggest that DHRS9 might be a useful diagnostic and prognostic marker for oral squamous cell carcinoma PMID: 30149992
DHRS9 is a specific and stable marker of human regulatory macrophages. PMID: 28594751
decreased expression of DHRS9 correlates with tumor progression and may serve as a potential prognostic biomarker in colorectal cancer PMID: 26254099
Even at early stages of malignant transformation, a significant decrease in ADH1B, ADH3, RDHL, and RALDH1 mRNA levels was observed in 82, 79, 73, and 64% of tumor specimens, respectively PMID: 27239845
Dehydrogenase/reductase SDR family member 9 is a moonlighting protein that functions as both a metabolic enzyme and as a transcriptional repressor. PMID: 16691198
expression of retinol dehydrogenase L is regulated by APC and CDX2 PMID: 15190067
retinoic acid-responsive genes are induced by Epstein-Barr virus lytic infection through induction of a retinol-metabolizing enzyme, DHRS9 PMID: 17244623
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Subcellular Location
Microsome membrane. Endoplasmic reticulum membrane. Note=Associated with microsomal membranes.
Protein Families
Short-chain dehydrogenases/reductases (SDR) family
Tissue Specificity
Highly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node.