DHRS9 Antibody

Code CSB-PA006867GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
DHRS9
Alternative Names
3 alpha hydroxysteroid dehydrogenase antibody; 3-@alpha-HSD antibody; 3-@alpha-hydroxysteroid dehydrogenase antibody; 3-alpha hydroxysteroid dehydrogenase antibody; 3-alpha-HSD antibody; 3alpha HSD antibody; Dehydrogenase/reductase SDR family member 9 antibody; DHRS9 antibody; DHRS9_HUMAN antibody; NADP dependent retinol dehydrogenase/reductase antibody; NADP-dependent retinol dehydrogenase/reductase antibody; RDH-E2 antibody; Rdh15 antibody; RDHE2 antibody; RDHL antibody; RDHTBE antibody; retinol dehydrogenase homolog antibody; Retinol dehydrogenase; tracheobronchiol epithelail cell-specific antibody; RETSDR8 antibody; SDR family; member 9 antibody; SDR9C4 antibody; short chain dehydrogenase/reductase family 9 antibody; short chain dehydrogenase/reductase family 9C; member 4 antibody; Short chain dehydrogenase/reductase retSDR8 antibody; Short-chain dehydrogenase/reductase retSDR8 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human DHRS9
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. Plays also a role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH.
Gene References into Functions
  1. The study findings suggest that DHRS9 might be a useful diagnostic and prognostic marker for oral squamous cell carcinoma PMID: 30149992
  2. DHRS9 is a specific and stable marker of human regulatory macrophages. PMID: 28594751
  3. decreased expression of DHRS9 correlates with tumor progression and may serve as a potential prognostic biomarker in colorectal cancer PMID: 26254099
  4. Even at early stages of malignant transformation, a significant decrease in ADH1B, ADH3, RDHL, and RALDH1 mRNA levels was observed in 82, 79, 73, and 64% of tumor specimens, respectively PMID: 27239845
  5. Dehydrogenase/reductase SDR family member 9 is a moonlighting protein that functions as both a metabolic enzyme and as a transcriptional repressor. PMID: 16691198
  6. expression of retinol dehydrogenase L is regulated by APC and CDX2 PMID: 15190067
  7. retinoic acid-responsive genes are induced by Epstein-Barr virus lytic infection through induction of a retinol-metabolizing enzyme, DHRS9 PMID: 17244623

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Subcellular Location
Microsome membrane. Endoplasmic reticulum membrane. Note=Associated with microsomal membranes.
Protein Families
Short-chain dehydrogenases/reductases (SDR) family
Tissue Specificity
Highly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node.
Database Links

HGNC: 16888

OMIM: 612131

KEGG: hsa:10170

STRING: 9606.ENSP00000316670

UniGene: Hs.179608

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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