DHTKD1 Antibody

Code CSB-PA842685ESR1HU
Size US$166
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  • Western blot
    All lanes: DHTKD1 antibody at 1.82µg/ml
    Lane 1: Mouse heart tissue
    Lane 2: A431 whole cell lysate
    Lane 3: MCF-7 whole cell lysate
    Lane 4: HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 103 kDa
    Observed band size: 103 kDa

  • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA842685ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA842685ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DHTKD1 Polyclonal antibody
Uniprot No.
Target Names
DHTKD1
Alternative Names
AMOXAD antibody; CMT2Q antibody; Dehydrogenase E1 and transketolase domain containing 1 antibody; Dehydrogenase E1 and transketolase domain containing protein 1 antibody; Dehydrogenase E1 and transketolase domain-containing protein 1 antibody; DHTK1_HUMAN antibody; dhtkd1 antibody; DKFZp762M115 antibody; KIAA1630 antibody; MGC3090 antibody; Probable 2 oxoglutarate dehydrogenase E1 component DHKTD1 mitochondrial antibody; Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1; mitochondrial antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial protein (1-280AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
Gene References into Functions
  1. DHTKD1 encodes the E1 subunit of the alpha-ketoadipic acid dehydrogenase complex PMID: 25860818
  2. DHTKD1 contributes to mitochondrial biogenesis and function maintenance. PMID: 24076469
  3. DHTKD1 mutations cause 2-aminoadipic and 2-oxoadipic aciduria. PMID: 23141293
  4. A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree. PMID: 23141294
Involvement in disease
Charcot-Marie-Tooth disease 2Q (CMT2Q); 2-aminoadipic 2-oxoadipic aciduria (AMOXAD)
Subcellular Location
Mitochondrion.
Protein Families
Alpha-ketoglutarate dehydrogenase family
Database Links

HGNC: 23537

OMIM: 204750

KEGG: hsa:55526

STRING: 9606.ENSP00000263035

UniGene: Hs.104980

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