DHX15 Antibody

Code CSB-PA006870LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: 293 whole cell lysate
    All lanes: DHX15 antibody at 3.7µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 91 kDa
    Observed band size: 91 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DHX15 Polyclonal antibody
Uniprot No.
Target Names
DHX15
Alternative Names
ATP dependent RNA helicase #46 antibody; ATP-dependent RNA helicase #46 antibody; DBP1 antibody; DDX15 antibody; DEADH box 15 antibody; DEAH (Asp Glu Ala His) box polypeptide 15 antibody; DEAH box polypeptide 15 antibody; DEAH box protein 15 antibody; DHX15 antibody; DHX15_HUMAN antibody; HRH2 antibody; Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 antibody; PRP43 antibody; PrPp43p antibody; RNA helicase 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 protein (371-502AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The DHX15 Antibody (Product code: CSB-PA006870LA01HU) is Non-conjugated. For DHX15 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA006870LB01HU DHX15 Antibody, HRP conjugated ELISA
FITC CSB-PA006870LC01HU DHX15 Antibody, FITC conjugated
Biotin CSB-PA006870LD01HU DHX15 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.
Gene References into Functions
  1. DHX15 regulates androgen receptor (AR) activity by modulating E3 ligase Siah2-mediated AR ubiquitination independent of its ATPase activity promoting prostate cancer progression. PMID: 28991234
  2. The crystal structure of human DHX15 reveals a domain organization of the mammalian DEAH/RHA family. PMID: 28580923
  3. Loss of DHX15 expression is associated with glioma. PMID: 28829764
  4. depletion of NKRF, XRN2 or DHX15 impairs an early pre-rRNA cleavage step. PMID: 28115624
  5. Mutation in DHX15 is associated with core-binding factor acute myeloid leukemia. PMID: 27798625
  6. Data indicate that DEAH-box RNA helicase DHX15/PRP43 stimulates the NF-kappaB and MAPK pathways downstream of virus-induced signaling adapter protein MAVS and contributes to MAVS-mediated cytokine production and apoptosis. PMID: 24782566
  7. The results suggest that activation of Prp43p by Gno1p/PINX1 within early pre-ribosomal particles is crucial for their subsequent maturation. PMID: 24823796
  8. Data suggest that G-patch domain of RBM5 is indispensable for its ability to interact with DHX15; RBM5 stimulates helicase activity of DHX15 in a G-patch domain-dependent manner. PMID: 22569250

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Subcellular Location
Nucleus. Nucleus, nucleolus.
Protein Families
DEAD box helicase family, DEAH subfamily, DDX15/PRP43 sub-subfamily
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 2738

OMIM: 603403

KEGG: hsa:1665

STRING: 9606.ENSP00000336741

UniGene: Hs.696074

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