DHX15 Antibody

Datasheet

Code	CSB-PA006870GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

O43143

Target Names

DHX15

Alternative Names

ATP dependent RNA helicase #46 antibody; ATP-dependent RNA helicase #46 antibody; DBP1 antibody; DDX15 antibody; DEADH box 15 antibody; DEAH (Asp Glu Ala His) box polypeptide 15 antibody; DEAH box polypeptide 15 antibody; DEAH box protein 15 antibody; DHX15 antibody; DHX15_HUMAN antibody; HRH2 antibody; Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 antibody; PRP43 antibody; PrPp43p antibody; RNA helicase 2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human DHX15

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.

Gene References into Functions

DHX15 regulates androgen receptor (AR) activity by modulating E3 ligase Siah2-mediated AR ubiquitination independent of its ATPase activity promoting prostate cancer progression. PMID: 28991234
The crystal structure of human DHX15 reveals a domain organization of the mammalian DEAH/RHA family. PMID: 28580923
Loss of DHX15 expression is associated with glioma. PMID: 28829764
depletion of NKRF, XRN2 or DHX15 impairs an early pre-rRNA cleavage step. PMID: 28115624
Mutation in DHX15 is associated with core-binding factor acute myeloid leukemia. PMID: 27798625
Data indicate that DEAH-box RNA helicase DHX15/PRP43 stimulates the NF-kappaB and MAPK pathways downstream of virus-induced signaling adapter protein MAVS and contributes to MAVS-mediated cytokine production and apoptosis. PMID: 24782566
The results suggest that activation of Prp43p by Gno1p/PINX1 within early pre-ribosomal particles is crucial for their subsequent maturation. PMID: 24823796
Data suggest that G-patch domain of RBM5 is indispensable for its ability to interact with DHX15; RBM5 stimulates helicase activity of DHX15 in a G-patch domain-dependent manner. PMID: 22569250

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Subcellular Location

Nucleus. Nucleus, nucleolus.

Protein Families

DEAD box helicase family, DEAH subfamily, DDX15/PRP43 sub-subfamily

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 2738

OMIM: 603403

KEGG: hsa:1665

STRING: 9606.ENSP00000336741

UniGene: Hs.696074

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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