DIAPH2 Antibody

Code CSB-PA006891ESR1HU
Size US$166
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  • Western blot
    All lanes: DIAPH2 antibody at 4.75μg/ml
    Lane 1: 293T whole cell lysate
    Lane 2: Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 126, 125 kDa
    Observed band size: 126 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006891ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA006891ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DIAPH2 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Dia 2 antibody; DIA antibody; Dia drome antibody; Dia2 antibody; Diap 2 antibody; Diap2 antibody; DIAP2_HUMAN antibody; DIAPH 2 antibody; Diaph2 antibody; Diaphanous 2 antibody; Diaphanous homolog 2 (Drosophila) antibody; Diaphanous homolog 2 antibody; Diaphanous related formin 2 antibody; Diaphanous-related formin-2 antibody; Diaphanous2 antibody; Diaphorase 2 antibody; Diaphorase2 antibody; DRF 2 antibody; DRF2 antibody; FLJ11167 antibody; OTTHUMP00000024270 antibody; OTTHUMP00000024271 antibody; OTTHUMP00000062171 antibody; POF 2 antibody; POF antibody; POF2 antibody; Protein diaphanous homolog 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein diaphanous homolog 2 protein (1-120AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
Gene References into Functions
  1. Low DIA2 expression is associated with breast cancer. PMID: 29596520
  2. DIAPH2 has been associated with premature ovarian insufficiency, an aging phenotype in humans. PMID: 24037343
  3. In podocytes, INF2 appears to be an important modulator of actin-dependent behaviors that are under the control of Rho/mDia signaling. PMID: 23620398
  4. Dia2 and DIP co-tether to nascent blebs and this linkage is required for bleb formation. PMID: 23024796
  5. Long HIV filopodial formation in infected dendritic cells was dependent on the formin diaphanous 2 (Diaph2) PMID: 22685410
  6. Our results indicated that DIAPH2 may be a polygenic pleiotropy for premature ovarian failure (POF) and AMD. PMID: 21386871
  7. Dia2 plays an important role in formation of lamellipodia. PMID: 18044991

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Involvement in disease
Premature ovarian failure 2A (POF2A)
Subcellular Location
[Isoform 3]: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.
Protein Families
Formin homology family, Diaphanous subfamily
Tissue Specificity
Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.
Database Links

HGNC: 2877

OMIM: 300108

KEGG: hsa:1730

STRING: 9606.ENSP00000321348

UniGene: Hs.226483

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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