DIMT1 Antibody

Datasheet

Code	CSB-PA892161LA01HU
Size	US$166
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Image	Western blot All lanes: DIMT1 antibody at 2μg/ml + Mouse thymus tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 35 kDa Observed band size: 35 kDa Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA892161LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA892161LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DIMT1 Polyclonal antibody

Uniprot No.

Q9UNQ2

Target Names

DIMT1

Alternative Names

18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase antibody; 18S rRNA dimethylase antibody; DIM1 antibody; DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) antibody; DIM1 dimethyladenosine transferase 1 homolog antibody; DIM1 dimethyladenosine transferase 1 like antibody; DIM1 dimethyladenosine transferase 1-like antibody; Dimethyladenosine transferase antibody; DIMT1 antibody; DIMT1_HUMAN antibody; DIMT1L antibody; HSA9761 antibody; HUSSY5 antibody; N''-adenosyl(rRNA) dimethyltransferase antibody; Probable 18S rRNA (adenine(1779) N(6)/adenine(1780) N(6)) dimethyltransferase antibody; Probable 18S rRNA dimethylase antibody; Probable dimethyladenosine transferase antibody; Probable S adenosylmethionine 6 N',N' adenosyl(rRNA) dimethyltransferase antibody; S adenosylmethionine 6 N',N' adenosyl(rRNA) dimethyltransferase antibody; S-adenosylmethionine-6-N'' antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Probable dimethyladenosine transferase protein (1-313AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DIMT1 Antibody (Product code: CSB-PA892161LA01HU) is Non-conjugated. For DIMT1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA892161LB01HU	DIMT1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA892161LC01HU	DIMT1 Antibody, FITC conjugated
Biotin	CSB-PA892161LD01HU	DIMT1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity.

Gene References into Functions

DIMT1 is overexpressed in gastric carcinoma and is significantly correlated with poor prognosis. PMID: 28601661
Studies show that miroRNA miR-210 acts as a tumor suppressor in hypoxic conditions by downregulating the 18S rRNA base methyltransferase (DIMT1)-interferon regulatory factor 4 (IRF4) axis. PMID: 28164410
DIMT1L and WBSCR22-TRMT112 are required for distinct pre-rRNA processing reactions leading to synthesis of 18S rRNA. Ribosome biogenesis requires the presence of the modification enzyme rather than its RNA-modifying catalytic activity. PMID: 25851604
Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection by activating STMN1 and DIMT1. PMID: 25187177

Subcellular Location

Nucleus, nucleoplasm. Nucleus, nucleolus.

Protein Families

Class I-like SAM-binding methyltransferase superfamily, rRNA adenine N(6)-methyltransferase family

Database Links

HGNC: 30217

OMIM: 612499

KEGG: hsa:27292

STRING: 9606.ENSP00000199320

UniGene: Hs.731665

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Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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