DLG5 Antibody

1. Loss of DLG5 expression promoted breast cancer progression by inactivating the Hippo signaling pathway and increasing nuclear YAP. PMID: 28169360
2. both polymorphisms of DLG5 are correlated with inflammatory bowel disease susceptibility in an ethnic-specific manner. PMID: 27633114
3. Low expression of DLG5 is associated with Crohn's disease. PMID: 27760079
4. Data found that Dlg5 expression was significantly lower in human hepatocellular carcinoma (HCC) tissues and indicate that Dlg5 acts as a novel regulator of invadopodium-associated invasion via Girdin and by interfering with the interaction between Girdin and Tks5, which might be important for Tks5 phosphorylation in HCC cells. PMID: 28390157
5. G113A variant may be significantly associated with Crohn's disease risk in children and colonic involvement (Meta-Analysis) PMID: 27338058
6. DLG5 inhibits the association between MST1/2 and large tumor suppressor homologs 1/2 (LATS1/2), uses its scaffolding function to link MST1/2 with MARK3, and inhibits MST1/2 kinase activity PMID: 28087714
7. Pooled data indicated no significant association between DLG5113G/A gene polymorphism and the development of Crohn's disease PMID: 27309475
8. These data suggest that inhibition of Dlg5 by DNA hypermethylation contributes to provoke invasive phenotypes in bladder tumor. PMID: 25478998
9. Findings demonstrate that Dlg5 interacts with and inhibits the activity of Girdin, thereby suppressing the migration of prostate cancer cells. PMID: 24662825
10. DLG5 plays a role in cell migration, cell adhesion, precursor cell division, cell proliferation, epithelial cell polarity maintenance, and transmission of extracellular signals to the membrane and cytoskeleton. PMID: 24910533
11. Overexpression of Dlg5 enhances the degradation of TGFBRI. PMID: 23624079
12. Polymorphisms in the DLG5 gene were found to be associated with Crohn's disease patients in Malaysia. PMID: 22118696
13. Examined the genetic association of DLG5 SNP P1371Q with inflammatory bowel disease and its interaction with R30Q in disease susceptibility. P1371Q is complementary to R30Q, with R30Q exhibiting a dominant effect in IBD susceptibility. PMID: 22065243
14. Increased expression of discs large homolog 5 gene is associated with ulcerative colitis. PMID: 21674725
15. In the studied population, DLG5 R30Q was associated with all forms of IBD. An elevated presence of the R30Q variant was observed in all members of a familial IBD registry PMID: 20037206
16. findings suggest that lp-dlg/KIAA0583 is a novel scaffolding protein that can link the vinexin-vinculin complex and beta-catenin at sites of cell-cell contact PMID: 12657639
17. Genetic variation in DLG5 is associated with inflammatory bowel disease PMID: 15107852
18. Collaboration of RAB6KIFL and DLG5 is likely to be involved in pancreatic cancer. PMID: 15665285
19. DLG5 constitutes a true inflammatory bowel diseases risk factor of modest effect PMID: 15841097
20. there are significant population allele frequency differences at the DLG5 gene [letter] PMID: 16391570
21. The G113A polymorphism of the DLG5 gene was completely absent in Greek Crohn disease cases as well as the Greek healthy population PMID: 16437728
22. R30Q variant constitutes a susceptibility factor for Crohn disease (CD) in men. PMID: 16446977
23. The results indicate a role for DLG5 variants in inflammatory bowel disease (IBD) susceptibility. PMID: 16450402
24. The initial report of DLG5 as a novel inflammatory bowel disease (IBD) susceptibility gene sparked a multitude of studies concerning its role in the aetiology of Crohn disease and IBD. PMID: 16773680
25. The R30Q variant in the DLG5 gene does not appear to be associated with an overall increase in the risk of disease in a British IBD cohort PMID: 16944184
26. DLG5 has a gender-specific role in the susceptibility of pediatric CD. Significant negative association found between DLG5 R30Q and CD in female children suggests DLG5 may have a protective effect in CD susceptibility for female children. PMID: 17156146
27. DLG5 gene missense mutation is associated with increased susceptibility to inflammatory bowel diseases in children. PMID: 17307543
28. polymorphism exerts a weak influence on Crohn's disease phenotype PMID: 17451203
29. the DLG5 haplotype A is associated with reduced risk of inflammatory bowel disease in the New Zealand Caucasian population PMID: 17455201
30. polymorphisms 3020insC in CARD15 and SNP rs2165047 in DLG5 may have a role in pediatric-onset Crohn's disease PMID: 17476680
31. DLG5 30Q is associated with a small reduction in risk of Crohn disease in women in a Caucasian cohort. PMID: 17693570
32. Results provide evidence that the scaffolding protein DLG5 belongs to the CARD protein family. PMID: 18335190
33. findings show that the inflammatory bowel disease-susceptibility gene DLG5 is also associated with gluten-sensitive enteropathy PMID: 18559397

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HGNC: 2904

OMIM: 604090

KEGG: hsa:9231

STRING: 9606.ENSP00000361467

UniGene: Hs.652690