DLG5 Antibody

Datasheet
Code CSB-PA823464LA01HU
Size US$299
Uniprot No. Q8TDM6
Image
  • Immunofluorescence staining of PC-3 cells with CSB-PA823464LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Protocols ELISA Protocol
Immunofluorescence (IF) Protocol
Immunogen Recombinant Human Disks large homolog 5 protein (1580-1704AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IF; Recommended dilution: IF:1:50-1:200
Relevance Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG), DLG5, KIAA0583 PDLG
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names DLG5
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Acts as a regulator of the Hippo signaling pathway
Subcellular Location Cell junction, Cell membrane, Peripheral membrane protein, Cell junction, synapse, postsynaptic cell membrane, postsynaptic density, Cytoplasm, cytoskeleton, cilium basal body
Protein Families MAGUK family
Tissue Specificity Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level) (PubMed:28169360). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal mus
Database Links

HGNC: 2904

OMIM: 604090

KEGG: hsa:9231

STRING: 9606.ENSP00000361467

UniGene: Hs.652690

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