DLX2 Antibody

1. Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis. PMID: 29242628
2. Authors characterized a BMP target gene, Distal-less homeobox 2 (DLX2), and found that DLX2 promoted apoptosis and neural differentiation of glioma-initiating cells. PMID: 28459464
3. DLX2 is a novel marker of poor prognosis and sorafenib resistance in patients with hepatocellular carcinoma. PMID: 27302463
4. High Ki67 expression is only present in 6.8% of CaP patients and is predictive of reduced survival and increased risk of metastasis, independent of PSA, Gleason score and D'Amico risk category. DLX2 is a novel marker of increased metastasis risk found in 73% patients and 8.2% showed co-expression with a high Ki67 score PMID: 27336609
5. High DLX-2 expression is associated with epithelial-mesenchymal transition in cancer. PMID: 26771232
6. DLX2 plays a crucial role in radioresistance, radiation-induced epithelial to mesenchymal transition and cancer stem cell marker expression, and the expression of DLX2 is regulated by Smad2/3 signaling in A549 and MDA-MB-231 cell lines. PMID: 26799321
7. DLX2 expression reduces the protein components of the TTI1/TTI2/TEL2 complex, a key complex required for the proper folding and stabilization of ATM and other members of the PIKK family kinase, leading to reduced ATM-p53 signaling and senescence bypass PMID: 26833729
8. Results showed that Dlx-2 is involved in TGF-beta- and Wnt-induced epithelial-mesenchymal transition, glycolytic switch, and mitochondrial repression by Snail activation. PMID: 25651912
9. The activation of DLX2 signaling might improve tissue regeneration mediated by MSCs of dental origin. Results provide insight into the mechanism underlying the directed differentiation of MSCs of dental origin. PMID: 24756434
10. Increased expression of DLX2 may correlate with the advanced stage of gastric adenocarcinoma, and it may contribute to tumor development. PMID: 23674878
11. overexpression of DLX2 indicated poor survival in the 83 glioblastoma multiforme patients PMID: 23331016
12. Dlx2 (and Dlx1) are required to generate cortical interneurons in the medial ganglionic eminence. PMID: 23312518
13. Dlx-2 may be involved in tumor progression via the regulation of metabolic stress-induced necrosis PMID: 21917150
14. MDA-MB-231 breast neoplasms expressed DLX2. PMID: 21108812
15. In corroboration with paired-like homeodomain protein 2 (PITX2) protein kinase C functional studies, a newly identified carboxyl-terminal PITX2 mutation associated with Axenfeld-Rieger syndrome demonstrates reduced phosphorylation. PMID: 15751970
16. In mice, biological and biochemical observations suggest that functional antagonism through heterodimer formation is a mechanism for regulating the transcriptional actions of Msx and Dlx homeoproteins. PMID: 9111364
17. results in mutated mice suggest that Dlx2 controls development of branchial arches and the forebrian, suggesting a role in craniofacil evolution PMID: 7590232
18. provides the sequence of human DLX2 and compares it to the murine gene. PMID: 8812481
19. In mice osteoblasts, both Dlx2 and Dlx5 are coordinately induced by BMP2 as early as 30 minutes into their growth and differentiation. PMID: 12957859

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HGNC: 2915

OMIM: 126255

KEGG: hsa:1746

STRING: 9606.ENSP00000234198

UniGene: Hs.419