DNAJA3 Antibody, FITC conjugated

Datasheet
Code CSB-PA836207LC01HU
Size US$299
Uniprot No. Q96EY1
Immunogen Recombinant Human DnaJ homolog subfamily A member 3, mitochondrial protein (86-184AA )
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog), DNAJA3, HCA57 TID1
Immunogen Species Human
Protocols ELISA Protocol
Research Area Signal Transduction
Target Names DNAJA3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Subcellular Location Mitochondrion matrix, Cytoplasm, cytosol, Cell junction, synapse, postsynaptic cell membrane, Peripheral membrane protein
Tissue Specificity Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
Database Links

HGNC: 11808

OMIM: 608382

KEGG: hsa:9093

STRING: 9606.ENSP00000262375

UniGene: Hs.459779

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