DNAJA3 Antibody

Datasheet
Code CSB-PA793564
Size US$299
Uniprot No. Q96EY1
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA793564(DNAJA3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA793564(DNAJA3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Full length fusion protein
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications ELISA,IHC;ELISA:1:2000-1:5000,IHC:1:25-1:100
Relevance This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias DnaJ (Hsp40) homolog, subfamily A, member 3
Immunogen Species Homo sapiens (Human)
Target Names DNAJA3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Subcellular Location Mitochondrion matrix, Cytoplasm, cytosol, Cell junction, synapse, postsynaptic cell membrane, Peripheral membrane protein
Tissue Specificity Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
Database Links

HGNC: 11808

OMIM: 608382

KEGG: hsa:9093

STRING: 9606.ENSP00000262375

UniGene: Hs.459779

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