DNAJA3 Antibody

Datasheet
Code CSB-PA007001GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. Q96EY1
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Human DNAJA3
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity Purified
Isotype IgG
Alias DnaJ (Hsp40) homolog, subfamily A, member 3;DNAJA3;FLJ45758;TID1;hTid-1 ;
Immunogen Species Homo sapiens (Human)
Target Names DNAJA3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
HGNC 11808
RGD 1306527
MGI 1933786
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Function Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Subcellular Location Mitochondrion matrix, Cytoplasm, cytosol, Cell junction, synapse, postsynaptic cell membrane, Peripheral membrane protein
Tissue Specificity Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
Database Links

HGNC: 11808

OMIM: 608382

KEGG: hsa:9093

STRING: 9606.ENSP00000262375

UniGene: Hs.459779

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