DNAJB8 Antibody

Code CSB-PA836779LA01HU
Size US$166
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  • Western blot
    All lanes: DNAJB8 antibody at 8µg/ml
    Lane 1: Hela whole cell lysate
    Lane 2: Mouse brain tissue
    Lane 3: Mouse liver tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 26 kDa
    Observed band size: 26 kDa

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA836779LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA836779LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DNAJB8 Polyclonal antibody
Uniprot No.
Target Names
DNAJB8
Alternative Names
DJ6 antibody; DnaJ (Hsp40) homolog; subfamily B; member 8 antibody; DnaJ homolog subfamily B member 8 antibody; Dnajb8 antibody; DNJB8_HUMAN antibody; mDj6 antibody; MGC33884 antibody; OTTHUMP00000216243 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human DnaJ homolog subfamily B member 8 protein (1-232AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The DNAJB8 Antibody (Product code: CSB-PA836779LA01HU) is Non-conjugated. For DNAJB8 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA836779LB01HU DNAJB8 Antibody, HRP conjugated ELISA
FITC CSB-PA836779LC01HU DNAJB8 Antibody, FITC conjugated
Biotin CSB-PA836779LD01HU DNAJB8 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The DNAJB8 antibody is produced by immunizing rabbits with the recombinant human DNAJB8 protein (1-232AA) and then antigen-affinity-purified from rabbit antiserum. It occurs as an unconjugated IgG. It shows reactivity with human and mouse DNAJB8 protein, which plays a role in the suppression of toxic polyglutamine (poly Q) protein aggregation and in vivo tumor initiation. This DNAJB8 antibody has been validated for use in ELISA, WB, and IHC applications.

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Target Background

Function
Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.
Gene References into Functions
  1. DNAJB8 is a central and versatile player in the protein aggregation and degradation system.DNAJB8 protein keeps Parkin C289G mutant protein in a soluble, degradation-competent form. PMID: 27713507
  2. Results show that DNAJB8 expression is induced by heat shock stress which increases side population cells and cancer stem-like cells. PMID: 29316077
  3. Taken together, the results indicate that DNAJB8 is expressed and has role in CRC CSC/CIC and that DNAJB8 is a novel target of CRC CSC/CIC-targeting immunotherapy. PMID: 24450541
  4. The mechanism of DNAJB6 and DNAJB8 is suppression of polyQ protein aggregation by directly binding the polyQ tract. PMID: 23612975
  5. Cancer stem-like cell (CSC) maintenance and that it offers a candidate for CSC-targeting immunotherapy in renal cell carcinoma PMID: 22552285
  6. DNAJB6b and DNAJB8 are superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins. PMID: 20159555

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Database Links

HGNC: 23699

OMIM: 611337

KEGG: hsa:165721

STRING: 9606.ENSP00000316053

UniGene: Hs.518241

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