DNAJB8 Antibody, HRP conjugated

Code CSB-PA836779LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DNAJB8 Polyclonal antibody
Uniprot No.
Target Names
DNAJB8
Alternative Names
DJ6 antibody; DnaJ (Hsp40) homolog; subfamily B; member 8 antibody; DnaJ homolog subfamily B member 8 antibody; Dnajb8 antibody; DNJB8_HUMAN antibody; mDj6 antibody; MGC33884 antibody; OTTHUMP00000216243 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human DnaJ homolog subfamily B member 8 protein (1-232AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.
Gene References into Functions
  1. DNAJB8 is a central and versatile player in the protein aggregation and degradation system.DNAJB8 protein keeps Parkin C289G mutant protein in a soluble, degradation-competent form. PMID: 27713507
  2. Results show that DNAJB8 expression is induced by heat shock stress which increases side population cells and cancer stem-like cells. PMID: 29316077
  3. Taken together, the results indicate that DNAJB8 is expressed and has role in CRC CSC/CIC and that DNAJB8 is a novel target of CRC CSC/CIC-targeting immunotherapy. PMID: 24450541
  4. The mechanism of DNAJB6 and DNAJB8 is suppression of polyQ protein aggregation by directly binding the polyQ tract. PMID: 23612975
  5. Cancer stem-like cell (CSC) maintenance and that it offers a candidate for CSC-targeting immunotherapy in renal cell carcinoma PMID: 22552285
  6. DNAJB6b and DNAJB8 are superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins. PMID: 20159555

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Database Links

HGNC: 23699

OMIM: 611337

KEGG: hsa:165721

STRING: 9606.ENSP00000316053

UniGene: Hs.518241

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