DNAJC15 Antibody

Datasheet
Code CSB-PA22849A0Rb
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Size US$299
Uniprot No. Q9Y5T4
Image
  • IHC image of CSB-PA22849A0Rb diluted at 1:300 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA22849A0Rb diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunogen Recombinant Human DnaJ homolog subfamily C member 15 protein (59-150AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:200-1:500
Relevance Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias DnaJ homolog subfamily C member 15 (Cell growth-inhibiting gene 22 protein) (Methylation-controlled J protein) (MCJ), DNAJC15, DNAJD1
Immunogen Species Human
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Research Area Signal Transduction
Target Names DNAJC15
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.
Involvement in disease Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.
Subcellular Location Mitochondrion inner membrane, Single-pass membrane protein
Tissue Specificity Expressed at highest levels in heart, followed by liver and kidney.
Database Links

HGNC: 20325

OMIM: 615339

KEGG: hsa:29103

STRING: 9606.ENSP00000368523

UniGene: Hs.438830

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