DNAJC7 Antibody

Code CSB-PA747689
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA747689(DNAJC7 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA747689(DNAJC7 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human seminoma tissue, Primary antibody: CSB-PA747689(DNAJC7 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
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Product Details

Uniprot No.
Target Names
DNAJC7
Alternative Names
DJ11 antibody; DJC7 antibody; DnaJ (Hsp40) homolog subfamily C member 7 antibody; DnaJ homolog subfamily C member 7 antibody; Dnajc7 antibody; DNJC7_HUMAN antibody; Tetratricopeptide repeat domain 2 antibody; Tetratricopeptide repeat protein 2 antibody; TPR repeat protein 2 antibody; TPR2 antibody; TTC2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Fusion protein of Human DNAJC7
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:5000
WB 1:500-1:2000
IHC 1:25-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm.
Gene References into Functions
  1. The data from the current study for the first time demonstrated increased serum polyglutamylated DNAJC7 as a potential biomarker for renal cell carcinoma early detection PMID: 26993597
  2. ubiquitin-proteasomal regulation of CCRP and HSP70 are important contributors to the regulation of cytoplasmic CAR levels, and hence the ability of CAR to respond to PB or PB-like inducers PMID: 24789201
  3. TPR2 exhibited strong interaction with glucocorticoid receptor and progesterone receptors. PMID: 20661446
  4. TPR2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. PMID: 12853476
  5. Data show that Tpr2 associates with Hsp90 and Hsp70 complexes, promoted the accumulation of Hsp70 in PR heterocomplexes in the presence of Hsp90. Thus, Tpr2 has the potential to regulate PR chaperoning. PMID: 18620420

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Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton.
Database Links

HGNC: 12392

OMIM: 601964

KEGG: hsa:7266

STRING: 9606.ENSP00000406463

UniGene: Hs.500156

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