DNMT3L Antibody, Biotin conjugated

1. DNMT3L overexpression is associated with Down syndrome. PMID: 26911678
2. the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility. PMID: 26647998
3. DNMT3L rs2070565 (genotype P = 0.007, allele P = 0.0026) confers an increased risk of developing schizophrenia at an early age in individuals with family history. PMID: 24859147
4. crystal structures of DNMT3A-DNMT3L (autoinhibitory form) and DNMT3A-DNMT3L-H3 (active form) complexes at 3.82 and 2.90 A resolution, respectively PMID: 25383530
5. DNMT3L can address DNMT3A/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A/B PMID: 24952347
6. CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX response element PMID: 24743422
7. DNMT3L is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review) PMID: 22671959
8. SNP rs2070565, as well as haplotypes AAA and GAA, may be associated with male infertility; DNMT3L may contribute to azoospermia susceptibility in humans PMID: 22116073
9. Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis. PMID: 22401780
10. mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages. PMID: 21126912
11. This study offers insights into the manner by which DNA methylation patterns are deposited and reveals a new level of interplay between members of the de novo DNMT family. PMID: 20838592
12. Processive methylation is enhanced 3-fold in the presence of DNMT3L, an inactive homolog of DNMT3A, therefore providing a mechanism for the previously described DNMT3L activation of DNMT3A. PMID: 20630873
13. We have identified loss of methylation at the DNMT3L promoter in ocular surface squamous neoplasia cases. PMID: 20670142
14. DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma. PMID: 20460473
15. DNMT3L exerts a major effect on the transcriptional regulation of a specific target gene, such as thymine DNA glycosylase PMID: 20428781
16. CG dinucleotide recognized by the Dnmt3a and Dnmt3L complex are distinctive at retroelements and imprinted domains. PMID: 19921333
17. DNMT3L stimulates de novo methylation by Dnmt3a. PMID: 12481029
18. The carboxyl-terminal half of DNMT3L was found to be responsible for the stimulation of the DNA methylation activity of Dnmt3a and Dnmt3b. PMID: 15105426
19. Regulates germ cell-specific gene expression and intracisternal A-particle suppression, which are critical for male germ cell proliferation and meiosis. PMID: 16211598
20. Dnmt3L-Dnmt3b interactions play an important role in the regulation of DNA methylation during mammalian development. PMID: 16543361
21. The acquisition of DNMT3L by a common ancestor of eutherians and marsupials might have been closely related to the evolution of imprinting. PMID: 16575165
22. Data show that binding of DNMT3L to DNMT3A2 promotes reorganization of DNMT3A2 subunits and leads to formation of specific complexes with enhanced DNA methyltransferase activity and increased S-adenosyl-L-methionine binding. PMID: 16829525
23. Crystallographic studies of human DNMT3L showed that the protein has a carboxy-terminal methyltransferase-like domain and an N-terminal cysteine-rich domain PMID: 17687327
24. the carboxy-terminal domain of human Dnmt3L interacts with the catalytic domain of Dnmt3a, demonstrating that Dnmt3L has dual functions of binding the unmethylated histone tail and activating DNA methyltransferase PMID: 17713477
25. Importance of DNA methylation profile at DNMT3L promoter not only as a promising biomarker for cervical cancer but also provides insight into the possible role of DNMT3L in cancer development. PMID: 17965599
26. DNMT3L(R271Q) is impaired in its ability to stimulate de novo DNA methylation by DNMT3A. PMID: 19246518
27. Overexpression of DNMT3L, which functions by regulating the activity of DNMT3A and DNMT3B, increased cellular proliferation and anchorage-independent growth. PMID: 19625766

Show More

Hide All

HGNC: 2980

OMIM: 606588

KEGG: hsa:29947

STRING: 9606.ENSP00000270172

UniGene: Hs.592165