DRG1 Antibody

Datasheet

Code	CSB-PA696333
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA696333(DRG1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA696333(DRG1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human fetal liver tissue, Human brain tissue, 293T cells, Hela cells, Primary antibody: CSB-PA696333(DRG1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
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Product Details
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Target Background

Product Details

Uniprot No.

Q9Y295

Target Names

DRG1

Alternative Names

Developmentally regulated GTP binding protein 1 antibody; Developmentally-regulated GTP-binding protein 1 antibody; DKFZp434N1827 antibody; DRG 1 antibody; DRG-1 antibody; DRG1 antibody; DRG1_HUMAN antibody; NEDD 3 antibody; NEDD-3 antibody; NEDD3 antibody; Neural precursor cell expressed developmentally down regulated protein 3 antibody; Neural precursor cell expressed developmentally down-regulated protein 3 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human DRG1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions.

Gene References into Functions

DRG1 was an important protein involved in spindle checkpoint signaling, and elevated levels of DRG1 caused lung adenocarcinoma and taxol resistance. PMID: 27626498
DRG-1 plays an important role in melanoma cell growth and transformation, indicating that DRG1 may represent a novel target for CD4(+) T cell-mediated immunotherapy in melanoma. PMID: 25993655
Lerepo4 action leaves Drg1 affinity for nucleotides unaffected, feasibly favoring a switch I reorientation, mainly via the TGS domain. PMID: 23711155
Drg-1 is a candidate metastasis suppressor gene for prostate cancer and may serve as a useful prognostic marker. PMID: 12702552
our results strongly suggest functional involvement of the Drg-1 gene in suppressing the metastatic advancement of human breast cancer. PMID: 15184886
The tumor metastasis suppressor gene Drg-1 suppresses metastasis of prostate tumor cells by inhibiting the invasive ability of the cells via down-regulation of the expression of the ATF3 gene. PMID: 17178897

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Subcellular Location

Nucleus. Cytoplasm. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes.

Protein Families

TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family

Tissue Specificity

High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.

Database Links

HGNC: 3029

OMIM: 603952

KEGG: hsa:4733

STRING: 9606.ENSP00000329715

UniGene: Hs.115242

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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