DRG1 Antibody

Code CSB-PA897524LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA897524LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA897524LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA897524LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Western Blot
    Positive WB detected in: HepG2 whole cell lysate
    All lanes:DRG1 antibody at 3.2μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 41 kDa
    Observed band size: 41 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DRG1 Polyclonal antibody
Uniprot No.
Target Names
DRG1
Alternative Names
Developmentally regulated GTP binding protein 1 antibody; Developmentally-regulated GTP-binding protein 1 antibody; DKFZp434N1827 antibody; DRG 1 antibody; DRG-1 antibody; DRG1 antibody; DRG1_HUMAN antibody; NEDD 3 antibody; NEDD-3 antibody; NEDD3 antibody; Neural precursor cell expressed developmentally down regulated protein 3 antibody; Neural precursor cell expressed developmentally down-regulated protein 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Developmentally-regulated GTP-binding protein 1 protein (173-228AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The DRG1 Antibody (Product code: CSB-PA897524LA01HU) is Non-conjugated. For DRG1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA897524LB01HU DRG1 Antibody, HRP conjugated ELISA
FITC CSB-PA897524LC01HU DRG1 Antibody, FITC conjugated
Biotin CSB-PA897524LD01HU DRG1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:200-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions.
Gene References into Functions
  1. DRG1 was an important protein involved in spindle checkpoint signaling, and elevated levels of DRG1 caused lung adenocarcinoma and taxol resistance. PMID: 27626498
  2. DRG-1 plays an important role in melanoma cell growth and transformation, indicating that DRG1 may represent a novel target for CD4(+) T cell-mediated immunotherapy in melanoma. PMID: 25993655
  3. Lerepo4 action leaves Drg1 affinity for nucleotides unaffected, feasibly favoring a switch I reorientation, mainly via the TGS domain. PMID: 23711155
  4. Drg-1 is a candidate metastasis suppressor gene for prostate cancer and may serve as a useful prognostic marker. PMID: 12702552
  5. our results strongly suggest functional involvement of the Drg-1 gene in suppressing the metastatic advancement of human breast cancer. PMID: 15184886
  6. The tumor metastasis suppressor gene Drg-1 suppresses metastasis of prostate tumor cells by inhibiting the invasive ability of the cells via down-regulation of the expression of the ATF3 gene. PMID: 17178897

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Subcellular Location
Nucleus. Cytoplasm. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes.
Protein Families
TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family
Tissue Specificity
High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.
Database Links

HGNC: 3029

OMIM: 603952

KEGG: hsa:4733

STRING: 9606.ENSP00000329715

UniGene: Hs.115242

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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