DRG2 Antibody

Code CSB-PA007186GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
DRG2
Alternative Names
Developmentally regulated GTP binding protein 2 antibody; Developmentally-regulated GTP-binding protein 2 antibody; DRG 2 antibody; DRG-2 antibody; drg2 antibody; DRG2_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human DRG2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation.
Gene References into Functions
  1. Taken together, our data demonstrate that DRG2 acts as a regulator of mitochondrial fission by controlling the expression of Drp1. PMID: 28363867
  2. Authors observed that knockdown of DRG2 in HeLa cells affected growth in a wound-healing assay, and tumorigenicity in nude mice xenografts. PMID: 27669826
  3. Results demonstrate that DRG2 is an endosomal protein and a key regulator of Rab5 deactivation and Tfn recycling. PMID: 26582392
  4. miR19153p functions as a silencer of apoptosis, which regulates lung cancer apoptosis via targeting DRG2/PBX2. PMID: 26572100
  5. Basal expression level of DRG2 is regulated by the Sp1 transcription factor. PMID: 21296692
  6. overexpression of DRG2 in Jurkat cells affects genes regulating cell-cycle arrest and apoptosis, and that these molecular changes may be important in the growth or differentiation of cells PMID: 15113831

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Subcellular Location
Nucleus. Cytoplasm.
Protein Families
TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family
Tissue Specificity
Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen, small intestine, lung and Leukocytes.
Database Links

HGNC: 3030

OMIM: 602986

KEGG: hsa:1819

STRING: 9606.ENSP00000225729

UniGene: Hs.78582

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