DTD1 Antibody

Datasheet

Code	CSB-PA007214GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q8TEA8

Target Names

DTD1

Alternative Names

bA379J5.3 antibody; bA555E18.1 antibody; C20orf88 antibody; D tyrosyl tRNA deacylase 1 homolog antibody; D-tyrosyl-tRNA(Tyr) deacylase 1 antibody; DNA unwinding element binding protein antibody; DTD1 antibody; DTD1_HUMAN antibody; DUE B antibody; DUEB antibody; HARS2 antibody; Histidyl tRNA synthetase 2 antibody; Histidyl-tRNA synthase-related antibody; MGC119131 antibody; MGC41905 antibody; pqn 68 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human DTD1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Possible ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes.; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.

Gene References into Functions

The state of DUE-B phosphorylation is maintained by the equilibrium between Cdc7-dependent phosphorylation and PP2A-dependent dephosphorylation. PMID: 25258324
LDI-PCR revealed a fusion between DTD1 exon 4 and PDGFRB exon 12 in the cases with t(5;14)(q33;q32) and t(5;20)(q33;p11). PMID: 24772479
DTD1 variants do not affect the abnormalities of the upper airways in aspirin-intolerant asthma patients PMID: 21479357
The coordinated binding of DUE-B and Cdc45 to origins and the physical interactions of DUE-B, Cdc45, and TopBP1 suggest that complexes of these proteins are necessary for replication initiation. PMID: 20065034
cloning and identification of novel cDNA which may be associated with FKBP25 PMID: 12392168
DUE-B, a c-myc DNA-unwinding element-binding protein, plays an important role in replication in vivo. PMID: 15653697

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Subcellular Location

Nucleus. Cytoplasm. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements (PubMed:20065034).

Protein Families

DTD family

Tissue Specificity

Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain.

Database Links

HGNC: 16219

OMIM: 610996

KEGG: hsa:92675

STRING: 9606.ENSP00000366672

UniGene: Hs.659442

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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