DTX1 Antibody, HRP conjugated

Code CSB-PA773055LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DTX1 Polyclonal antibody
Uniprot No.
Target Names
DTX1
Alternative Names
Deltex 1; E3 ubiquitin ligase antibody; Deltex antibody; Deltex homolog 1 (Drosophila) antibody; Deltex homolog 1 antibody; Deltex protein 1 antibody; Deltex-1 antibody; Deltex1 antibody; dtx1 antibody; DTX1_HUMAN antibody; E3 ubiquitin protein ligase DTX1 antibody; E3 ubiquitin-protein ligase DTX1 antibody; FXI-T1 antibody; Fxit 1 antibody; Fxit1 antibody; hDTX1 antibody; hDx 1 antibody; mDTX1 antibody; Protein deltex 1 antibody; Protein deltex-1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human E3 ubiquitin-protein ligase DTX1 protein (261-410AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
Gene References into Functions
  1. Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma PMID: 28183850
  2. PI5P4Kgamma positively regulates the DTX1-mediated Notch pathway by promoting receptor recycling PMID: 29440432
  3. Data indicate that decreased expression of deltex E3 ubiquitin ligase 1 (DTX1) in head and neck squamous cell carcinoma (HNSCC) tumors maybe associated with NOTCH pathway activation and increased migration potential. PMID: 28146432
  4. Two SNPs (rs2384077 and rs10744794) in an intron of DTX1 and the linkage disequilibrium (LD) block are significantly associated with the immune response to HBV vaccination. PMID: 26894927
  5. this study reports the identification of two new hGIP-interacting partners, DTX1 and STAU1. PMID: 23395680
  6. characterization of two genes expressed in centroblasts of human tonsils: deltex (Drosophila) homolog 1 (DTX1), which is related to the Notch pathway and a new Kelch-like protein, KLHL6 PMID: 12617994
  7. It is reported that BBAP and the human family of DTX proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on their capacity for self-ubiquitination. PMID: 12670957

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Subcellular Location
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
Protein Families
Deltex family
Tissue Specificity
Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells.
Database Links

HGNC: 3060

OMIM: 602582

KEGG: hsa:1840

STRING: 9606.ENSP00000257600

UniGene: Hs.372152

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