DTX2 Antibody

Code CSB-PA007222GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
DTX2
Alternative Names
Deltex 2 antibody; deltex homolog 2 (Drosophila) antibody; deltex; Drosophila; homolog of; 2 antibody; Deltex2 antibody; DTX2 antibody; DTX2_HUMAN antibody; hDTX2 antibody; Highly similar to hPMSR6 [H.sapiens] antibody; KIAA1528 antibody; Probable E3 ubiquitin-protein ligase DTX2 antibody; Protein deltex 2 antibody; Protein deltex-2 antibody; RING finger protein 58 antibody; RNF58 antibody; Zinc ion binding protein antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human DTX2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Gene References into Functions
  1. DTX2 is a gene encoding a WWE-RING-finger protein and involved in regulating heart development and heart functions. PMID: 17286044
  2. It is reported that BBAP and the human family of DTX proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on their capacity for self-ubiquitination. PMID: 12670957
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Deltex family
Database Links

HGNC: 15973

OMIM: 613141

KEGG: hsa:113878

STRING: 9606.ENSP00000322885

UniGene: Hs.187058

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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