DTX2 Antibody

Datasheet
Code CSB-PA803123ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q86UW9
Image
  • Western blot
    All lanes: DTX2 antibody at 1μg/ml + HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 68, 63 kDa
    Observed band size: 68, 92 kDa

  • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA803123ESR2HU at dilution of 1:100

Immunogen Recombinant Human Probable E3 ubiquitin-protein ligase DTX2 protein (1-280AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200
Relevance Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2), DTX2, KIAA1528 RNF58
Immunogen Species Human
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Research Area Stem Cells
Target Names DTX2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Still Have Questions? Leave a Message or Start an on-line Chat
Function Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Subcellular Location Cytoplasm, Nucleus
Protein Families Deltex family
Database Links

HGNC: 15973

OMIM: 613141

KEGG: hsa:113878

STRING: 9606.ENSP00000322885

UniGene: Hs.187058

Pathway Notch signaling pathway

Related Products

DTX2 Antibodies

DTX2 Antibodies for Homo sapiens (Human)

DTX2 Antibodies for Human

DTX2 Proteins

DTX2 Proteins for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.

Wait!

Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now!

We don't deal in spam.