DTX2 Antibody

Datasheet
Code CSB-PA900594
Former Code(s) CSB-PA114222
Size US$299
Uniprot No. Q86UW9
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA900594(DTX2 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
Immunogen Fusion protein of Human DTX2
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications ELISA,IHC;ELISA:1:1000-1:2000,IHC:1:10-1:50
Relevance DTX2 functions as an E3 ubiquitin ligase. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias deltex 2, E3 ubiquitin ligase
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Target Names DTX2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Subcellular Location Cytoplasm, Nucleus
Protein Families Deltex family
Database Links

HGNC: 15973

OMIM: 613141

KEGG: hsa:113878

STRING: 9606.ENSP00000322885

UniGene: Hs.187058

Pathway Notch signaling pathway

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