DVL3 Antibody

Code CSB-PA007287GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
DVL3
Alternative Names
Dishevelled 3 (homologous to Drosophila dsh) antibody; Dishevelled 3 antibody; Dishevelled 3; dsh homolog (Drosophila) antibody; Dishevelled; dsh homolog 3 (Drosophila) antibody; Dishevelled-3 antibody; DSH homolog 3 antibody; dvl3 antibody; DVL3_HUMAN antibody; KIAA0208 antibody; OTTHUMP00000210777 antibody; OTTHUMP00000210778 antibody; Segment polarity protein dishevelled homolog DVL 3 antibody; Segment polarity protein dishevelled homolog DVL-3 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human DVL3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in the signal transduction pathway mediated by multiple Wnt genes.
Gene References into Functions
  1. Dvl3 is overexpressed in human HCCs. The NP-Dvl3 is the more stable and active form of the protein and enhances HCC stemness. PMID: 28455968
  2. Studied and identified candidate biomarkers of biochemical recurrence (BCR) of prostate adenocarcinoma by integrating reverse-phase protein array (RPPA) and mRNA datafrom The Cancer Genome Atlas (TCGA). Found DVL3 was expressed in patients with a higher risk of BCR. DVL3 may be a novel and easily applicable recurrence predictor of localised prostate adenocarcinoma. PMID: 28107606
  3. Genetic changes between MLH1 and MSH2 were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 and DVL3 genes (p = 0.034). PMID: 28705114
  4. Kif26b, together with Dvl3/Daam1, initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells. PMID: 26792835
  5. DVL3 transcripts decreased in individuals with major depressive disorder PMID: 26008736
  6. we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2. PMID: 27008544
  7. All variants in DVL3 result in a -1 frameshift, indicating that these highly specific alterations might be a common cause of dominant Robinow syndrome. PMID: 26924530
  8. data suggest that miR-204-5p regulates adipogenesis by controlling DVL3 expression and subsequently inhibiting the activation of the Wnt/beta-catenin signaling pathway. PMID: 25847080
  9. Tumors that responded to IGFIR inhibition contain relatively lower levels of DVL3 protein than resistant tumors. PMID: 25168481
  10. data (i) support previous the assumption that CK1 acts via phosphorylation of distinct residues as the activator as well as the shut-off signal of Wnt/beta-catenin signaling and (ii) suggest that CK1 acts on Dvl via different mechanism than Fzd5. PMID: 24993822
  11. AMPK activators suppress cervical cancer cell growth by impairing DVL3 protein synthesis via AMPK/mTOR signaling and/or partially promoting the proteasomal degradation of DVL3 PMID: 23301094
  12. A harmful p.Ser175Gly substitution & 3 benign variants (p.Ile353Val, p.Ile384Val, & p.Ala641Thr) were found in a cohort of patients with neural tube defects but not in controls. PMID: 22892949
  13. Dvl3 protein transduce signals via the Wnt proteins non canonical pathways, namely via NFAT protein and Src kinase and novel NPM-ALK interacting proteins and possibly NPM-ALK substrates. PMID: 23022960
  14. Letter: report expression of dishevelled-3 and EAAT1 and glutamine metabolism in malignant pleural mesothelioma. PMID: 22569537
  15. Identification of novel post translational modifications of DVL3 by liquid chromatography coupled LTQ-Orbitrap analysis. PMID: 22612246
  16. In HEK293T cells with intact Wnt signaling, Rac1b is tethered to these same gene promoters independent of Wnt3A stimulation and is further observed to recruit Dishevelled and beta-catenin in the absence of Wnt3A stimulation. PMID: 21667018
  17. The facilitation of Prickle-1 on Dvl3 degradation and the suppression of beta-catenin activity and cell growth suggest that Prickle-1 is a negative regulator of the Wnt/beta-catenin signaling pathway PMID: 17030191

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Involvement in disease
Robinow syndrome, autosomal dominant 3 (DRS3)
Subcellular Location
Cytoplasm.
Protein Families
DSH family
Database Links

HGNC: 3087

OMIM: 601368

KEGG: hsa:1857

STRING: 9606.ENSP00000316054

UniGene: Hs.388116

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