EARS2 Antibody

Datasheet

Citations (1)

Code	CSB-PA705509LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA705509LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA705509LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EARS2 Polyclonal antibody

Uniprot No.

Q5JPH6

Target Names

EARS2

Alternative Names

3230401I01Rik antibody; AL024049 antibody; COXPD12 antibody; EARS 2 antibody; ears2 antibody; GluRS antibody; Glutamate--tRNA ligase antibody; Glutamyl tRNA synthetase 2 mitochondrial antibody; KIAA1970 antibody; mitochondrial antibody; mKIAA1970 antibody; MSE1 antibody; Probable glutamyl tRNA synthetase; mitochondrial antibody; Probable glutamyl-tRNA synthetase antibody; RGD1307904 antibody; SYEM_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Probable glutamate--tRNA ligase, mitochondrial protein (42-166AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The EARS2 Antibody (Product code: CSB-PA705509LA01HU) is Non-conjugated. For EARS2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA705509LB01HU	EARS2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA705509LC01HU	EARS2 Antibody, FITC conjugated
Biotin	CSB-PA705509LD01HU	EARS2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Citations

B cell dysfunction in thalamus and brainstem involvement and high lactate caused by novel mutation of EARS2 gene Y Wen, Y Huang, W Zhang, P Chen, X Hu, X Xiong,Italian Journal of Pediatrics,2025

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

Gene References into Functions

This study presented that a new neurological disease, early-onset leukoencephalopathy with thalamus and brainstem involvement and high lactate, defined by a peculiar biphasic clinical course and caused by mutations in a single gene, EARS2. PMID: 22492562

Involvement in disease

Combined oxidative phosphorylation deficiency 12 (COXPD12)

Subcellular Location

Mitochondrion matrix.

Protein Families

Class-I aminoacyl-tRNA synthetase family, Glutamate--tRNA ligase type 1 subfamily

Database Links

HGNC: 29419

OMIM: 612799

KEGG: hsa:124454

STRING: 9606.ENSP00000343488

UniGene: Hs.620541

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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