ECD Antibody, HRP conjugated

Datasheet

Code	CSB-PA007370LB01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ECD Polyclonal antibody

Uniprot No.

O95905

Target Names

ECD

Alternative Names

ecd antibody; ECD_HUMAN antibody; Ecdysoneless homolog antibody; hSGT1 antibody; Human suppressor of GCR two antibody; Protein ecdysoneless homolog antibody; SGT 1 antibody; SGT1 protein antibody; Suppressor of GCR2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein ecdysoneless homolog protein (1-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.

Gene References into Functions

The interaction of ECD with RUVBL1, and its CK2-mediated phosphorylation, independent of its interaction with PIH1D1, are important for its cell cycle regulatory function. PMID: 26711270
Ecdysoneless and H-Ras expressing human mammary epithelial cells form tumors in NOD/SCID mice. PMID: 25616580
Ecd is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells. PMID: 22977192
Ecd as a novel marker for breast cancer progression and show that levels of Ecd expression predict poorer survival in Her2/neu overexpressing breast cancer patients. PMID: 22270930
Ecd localizes to both nucleus & cytoplasm & shuttles between the nucleus and cytoplasm; however, it exhibits strong nuclear export. Based on previous yeast studies & evidence provided here, we suggest that Ecd functions as a transcriptional regulator. PMID: 19919181

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

ECD family

Tissue Specificity

Highly expressed in muscle and heart. Over-expressed in pancreatic and breast cancers.

Database Links

HGNC: 17029

OMIM: 616464

KEGG: hsa:11319

STRING: 9606.ENSP00000401566

UniGene: Hs.631822

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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