ECD Antibody

Datasheet

Code	CSB-PA007370LA01HU
Size	US$166
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Image	Western blot All lanes: ECD antibody at 6µg/ml Lane 1: Hela whole cell lysate Lane 2: U251 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 73, 68, 77 kDa Observed band size: 73 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ECD Polyclonal antibody

Uniprot No.

O95905

Target Names

ECD

Alternative Names

ecd antibody; ECD_HUMAN antibody; Ecdysoneless homolog antibody; hSGT1 antibody; Human suppressor of GCR two antibody; Protein ecdysoneless homolog antibody; SGT 1 antibody; SGT1 protein antibody; Suppressor of GCR2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein ecdysoneless homolog protein (1-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ECD Antibody (Product code: CSB-PA007370LA01HU) is Non-conjugated. For ECD Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA007370LB01HU	ECD Antibody, HRP conjugated	ELISA
FITC	CSB-PA007370LC01HU	ECD Antibody, FITC conjugated
Biotin	CSB-PA007370LD01HU	ECD Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.

Gene References into Functions

The interaction of ECD with RUVBL1, and its CK2-mediated phosphorylation, independent of its interaction with PIH1D1, are important for its cell cycle regulatory function. PMID: 26711270
Ecdysoneless and H-Ras expressing human mammary epithelial cells form tumors in NOD/SCID mice. PMID: 25616580
Ecd is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells. PMID: 22977192
Ecd as a novel marker for breast cancer progression and show that levels of Ecd expression predict poorer survival in Her2/neu overexpressing breast cancer patients. PMID: 22270930
Ecd localizes to both nucleus & cytoplasm & shuttles between the nucleus and cytoplasm; however, it exhibits strong nuclear export. Based on previous yeast studies & evidence provided here, we suggest that Ecd functions as a transcriptional regulator. PMID: 19919181

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

ECD family

Tissue Specificity

Highly expressed in muscle and heart. Over-expressed in pancreatic and breast cancers.

Database Links

HGNC: 17029

OMIM: 616464

KEGG: hsa:11319

STRING: 9606.ENSP00000401566

UniGene: Hs.631822

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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