EDA2R Antibody

Code CSB-PA640379
Size US$299 How to order?
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA640379(EDA2R Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA640379(EDA2R Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: CSB-PA640379(EDA2R Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
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Product Details

Uniprot No. Q9HAV5
Target Names EDA2R
Alternative Names 9430060M22Rik antibody; Ectodysplasin A2 isoform receptor antibody; Ectodysplasin A2 receptor antibody; EDA A2R antibody; EDA-A2 receptor antibody; EDA2R antibody; EDAA2R antibody; MGC124099 antibody; OTTMUSP00000019574 antibody; OTTMUSP00000019575 antibody; RP23-188N15.1 antibody; TNFRSF27 antibody; TNR27_HUMAN antibody; Tumor necrosis factor receptor superfamily member 27 antibody; Tumor necrosis factor receptor superfamily member XEDAR antibody; X linked ectodysplasin A2 receptor antibody; X linked ectodysplasin receptor antibody; X-linked ectodysplasin-A2 receptor antibody; XEDAR antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Fusion protein of Human EDA2R
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
Gene References into Functions
  1. We found evidence for AR but not EDA2R as the candidate gene at the androgenetic alopecia risk locus on chromosome X. PMID: 27060448
  2. EDA-A2 and its receptor XEDAR are overexpressed in epithelial cells of salivary glands in Sjogren's syndrome patients, in comparison with healthy individuals. The EDA-A2/XEDAR system in these cells is involved in the induction of apoptosis via CASP3 activation. PMID: 26659383
  3. XEDAR activates the non-canonical NF-kappaB pathway. PMID: 26260321
  4. To investigate the evolutionary history of the EDA2R/AR intergenic region, we characterized the haplotype structure of 52 of its highly differentiated SNPs. Nearly all human X chromosomes carry one of two modal haplotypes for these 52 SNPs. PMID: 23959643
  5. The results suggest that EDA2R confers susceptibility to early onset female pattern hair loss PMID: 22309448
  6. association in dental crowding in the Hong Kong Chinese population PMID: 21724072
  7. A crucial role of the EDA-A2/ectodysplasin A2 (XEDAR) interaction is revealed in the p53-signaling pathway. PMID: 20501644
  8. because no frequent variant other than rs1385699 has been reported in EDA2R in the European population, it is probable that the causative variant(s) modifies the expression of one or more flanking genes, i.e. AR and EDA2R PMID: 20199557
  9. Results establish a major role of TRAF3 and -6 in X-linked ectodermal dysplasia receptor (XEDAR) signaling and in the process of ectodermal differentiation. PMID: 12270937
  10. XEDAR belongs to a novel class of death receptors that lack a discernible death domain but are capable of activating apoptosis in a caspase 8- and FADD-dependent fashion PMID: 15280356
  11. isoforms of EDA-A5 and A5',activated NF-kappaB through receptors EDAR and XEDAR PMID: 16423472
  12. The androgen receptor gene and EDA2R are significantly associated with androgenetic alopecia. PMID: 18385763
  13. androgen receptor/ectodysplasin A2 receptor haplotype may have a role in male pattern baldness PMID: 19373488
  14. XEDAR is a putative tumor suppressor that could prevent malignant transformation and tumor progression by regulating apoptosis and anoikis. PMID: 19543321

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Subcellular Location Membrane; Single-pass type III membrane protein.
Database Links

HGNC: 17756

OMIM: 300276

KEGG: hsa:60401

UniGene: Hs.302017

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