EDA2R Antibody

Datasheet

Code	CSB-PA881011ESR1HU
Size	US$166
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Image	Western blot All lanes: Tumor necrosis factor receptor superfamily member 27 antibody at 6μg/ml Lane 1: HepG2 whole cell lysate Lane 2: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 33, 36 kDa Observed band size: 33 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA881011ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA881011ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EDA2R Polyclonal antibody

Uniprot No.

Q9HAV5

Target Names

EDA2R

Alternative Names

9430060M22Rik antibody; Ectodysplasin A2 isoform receptor antibody; Ectodysplasin A2 receptor antibody; EDA A2R antibody; EDA-A2 receptor antibody; EDA2R antibody; EDAA2R antibody; MGC124099 antibody; OTTMUSP00000019574 antibody; OTTMUSP00000019575 antibody; RP23-188N15.1 antibody; TNFRSF27 antibody; TNR27_HUMAN antibody; Tumor necrosis factor receptor superfamily member 27 antibody; Tumor necrosis factor receptor superfamily member XEDAR antibody; X linked ectodysplasin A2 receptor antibody; X linked ectodysplasin receptor antibody; X-linked ectodysplasin-A2 receptor antibody; XEDAR antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Tumor necrosis factor receptor superfamily member 27 protein (1-138AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.

Gene References into Functions

We found evidence for AR but not EDA2R as the candidate gene at the androgenetic alopecia risk locus on chromosome X. PMID: 27060448
EDA-A2 and its receptor XEDAR are overexpressed in epithelial cells of salivary glands in Sjogren's syndrome patients, in comparison with healthy individuals. The EDA-A2/XEDAR system in these cells is involved in the induction of apoptosis via CASP3 activation. PMID: 26659383
XEDAR activates the non-canonical NF-kappaB pathway. PMID: 26260321
To investigate the evolutionary history of the EDA2R/AR intergenic region, we characterized the haplotype structure of 52 of its highly differentiated SNPs. Nearly all human X chromosomes carry one of two modal haplotypes for these 52 SNPs. PMID: 23959643
The results suggest that EDA2R confers susceptibility to early onset female pattern hair loss PMID: 22309448
association in dental crowding in the Hong Kong Chinese population PMID: 21724072
A crucial role of the EDA-A2/ectodysplasin A2 (XEDAR) interaction is revealed in the p53-signaling pathway. PMID: 20501644
because no frequent variant other than rs1385699 has been reported in EDA2R in the European population, it is probable that the causative variant(s) modifies the expression of one or more flanking genes, i.e. AR and EDA2R PMID: 20199557
Results establish a major role of TRAF3 and -6 in X-linked ectodermal dysplasia receptor (XEDAR) signaling and in the process of ectodermal differentiation. PMID: 12270937
XEDAR belongs to a novel class of death receptors that lack a discernible death domain but are capable of activating apoptosis in a caspase 8- and FADD-dependent fashion PMID: 15280356
isoforms of EDA-A5 and A5',activated NF-kappaB through receptors EDAR and XEDAR PMID: 16423472
The androgen receptor gene and EDA2R are significantly associated with androgenetic alopecia. PMID: 18385763
androgen receptor/ectodysplasin A2 receptor haplotype may have a role in male pattern baldness PMID: 19373488
XEDAR is a putative tumor suppressor that could prevent malignant transformation and tumor progression by regulating apoptosis and anoikis. PMID: 19543321

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Subcellular Location

Membrane; Single-pass type III membrane protein.

Database Links

HGNC: 17756

OMIM: 300276

KEGG: hsa:60401

UniGene: Hs.302017

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Protein Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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