EDC4 Antibody, FITC conjugated

Code CSB-PA744034LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EDC4 Polyclonal antibody
Uniprot No.
Target Names
EDC4
Alternative Names
autoantigen antibody; Autoantigen Ge 1 antibody; Autoantigen Ge-1 antibody; Autoantigen Ge1 antibody; Autoantigen RCD 8 antibody; Autoantigen RCD-8 antibody; Autoantigen RCD8 antibody; edc4 antibody; EDC4_HUMAN antibody; Enhancer of mRNA decapping 4 antibody; Enhancer of mRNA-decapping protein 4 antibody; Ge 1 antibody; Hedls antibody; Human enhancer of decapping large subunit antibody; RCD 8 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Enhancer of mRNA-decapping protein 4 protein (753-952AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).
Gene References into Functions
  1. EDC4 plays a key role in homologous recombination by stimulating end resection at double-strand breaks. PMID: 29511213
  2. The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6. PMID: 25970328
  3. EDC4 is a processing body (P-body) component. PMID: 24858563
  4. The data indicates that DCP2 activation by DCP1 occurs preferentially on the EDC4 scaffold, which may serve to couple DCP2 activation by DCP1 with 5'-to-3' mRNA degradation by XRN1 in human cells. PMID: 24510189
  5. EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies PMID: 22982864

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Subcellular Location
Cytoplasm, P-body. Nucleus.
Protein Families
WD repeat EDC4 family
Database Links

HGNC: 17157

OMIM: 606030

KEGG: hsa:23644

STRING: 9606.ENSP00000351811

UniGene: Hs.75682

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