EDC4 Antibody

Code CSB-PA007394GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
EDC4
Alternative Names
autoantigen antibody; Autoantigen Ge 1 antibody; Autoantigen Ge-1 antibody; Autoantigen Ge1 antibody; Autoantigen RCD 8 antibody; Autoantigen RCD-8 antibody; Autoantigen RCD8 antibody; edc4 antibody; EDC4_HUMAN antibody; Enhancer of mRNA decapping 4 antibody; Enhancer of mRNA-decapping protein 4 antibody; Ge 1 antibody; Hedls antibody; Human enhancer of decapping large subunit antibody; RCD 8 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human EDC4
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).
Gene References into Functions
  1. EDC4 plays a key role in homologous recombination by stimulating end resection at double-strand breaks. PMID: 29511213
  2. The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6. PMID: 25970328
  3. EDC4 is a processing body (P-body) component. PMID: 24858563
  4. The data indicates that DCP2 activation by DCP1 occurs preferentially on the EDC4 scaffold, which may serve to couple DCP2 activation by DCP1 with 5'-to-3' mRNA degradation by XRN1 in human cells. PMID: 24510189
  5. EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies PMID: 22982864

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Subcellular Location
Cytoplasm, P-body. Nucleus.
Protein Families
WD repeat EDC4 family
Database Links

HGNC: 17157

OMIM: 606030

KEGG: hsa:23644

STRING: 9606.ENSP00000351811

UniGene: Hs.75682

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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