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EFNA3 Antibody

Datasheet
Code CSB-PA007462ESR2HU
Size US$166
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  • Immunohistochemistry(IHC) 1- EFNA3 Antibody

    Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA007462ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EFNA3 Polyclonal antibody
Uniprot No.
P52797
Target Names
EFNA3
Alternative Names
EFL 2 antibody; EFL-2 antibody; EFL2 antibody; EFN A3 antibody; EFNA 3 antibody; Efna3 antibody; EFNA3_HUMAN antibody; EHK1 L antibody; EHK1 ligand antibody; EHK1-L antibody; EHK1L antibody; EPH related receptor tyrosine kinase ligand 3 antibody; EPH-related receptor tyrosine kinase ligand 3 antibody; Ephrin-A3 antibody; EphrinA3 antibody; EPLG 3 antibody; EPLG3 antibody; LERK 3 antibody; LERK-3 antibody; LERK3 antibody; Ligand of eph related kinase 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ephrin-A3 protein (23-214AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
Gene References into Functions
  1. E2F3 and ephrin A3 are putative targets of miR-210, and their protein expression was up-regulated in the angiosarcoma cells PMID: 28739548
  2. Results show that EFNA3 serves as a tumor suppressor in malignant peripheral nerve sheath tumor cells and it may play a critical role in the FAK signaling and VEGF-associated tumor angiogenesis pathway. PMID: 25955218
  3. The present study provides evidence that microglia upregulates endothelial ephrin-A3 and ephrin-A4 to facilitate in vitro angiogenesis of brain endothelial cells, which is mediated by microglia-released TNF-alpha. PMID: 25070915
  4. EphA2/ephrin-A3 interactions may play a role in the localization and network of Langerhans cells in the epithelium and in the regulation of their trafficking. PMID: 12907451
  5. analysis of molecular surfaces in ephrin-A5 essential for a functional interaction with EphA3 PMID: 15901737
  6. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. PMID: 18417479
  7. EphA3 mutants with constitutively-released kinase domains efficiently support shedding, even when their kinase is disabled. Our data suggest that this phosphorylation-activated conformational switch of EphA3 directly controls ADAM-mediated shedding. PMID: 19823572

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Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Protein Families
Ephrin family
Tissue Specificity
Expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes.
Database Links

HGNC: 3223

OMIM: 601381

KEGG: hsa:1944

STRING: 9606.ENSP00000357393

UniGene: Hs.516656

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Related pathways
MAPK signaling pathway PI3K-Akt signaling pathway Ras signaling pathway Rap1 signaling pathway
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