EHF Antibody

1. A negative correlation between EHF protein and miR206 expression. PMID: 28714026
2. Human prostate tumors with IL-6 elevation and loss of ESE3/EHF were associated with STAT3 activation and displayed upregulation of genes related to cell adhesion, cancer stem-like and metastatic spread. PMID: 27732936
3. EHF is a novel functional oncogene in thyroid cancer by transcriptionally regulating HER2 and HER3, and may represent a potential therapeutic target for this cancer PMID: 27517321
4. The role of EHF in modifying Cystic Fibrosis lung disease severity. PMID: 28549169
5. is a novel functional oncogene in gastric cancer by regulating the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. PMID: 27787520
6. tight control by ESE3/EHF over the Lin28/let-7 axis is a critical barrier to malignant transformation. PMID: 27197175
7. ESE3 as a negative regulator of pancreatic ductal adenocarcinomas (PDAC) progression and metastasis by enforcing E-cadherin upregulation. PMID: 27923832
8. EHF activates expression of the SAM pointed domain-containing ETS transcription factor, which contributes to goblet cell hyperplasia. PMID: 28461336
9. Results found that EHF was elevated in ovarian cancer tissues and correlated with short survival. Its overexpression in ovarian cancer cells promoted cell growth and metastasis, and inhibited cell apoptosis. PMID: 26258986
10. This study suggests that ESE3 plays an important role in the carcinogenesis of Esophageal Squamous Cell Carcinoma through changes in subcellular localization and may act as a tumor suppressor gene in Esophageal Squamous Cell Carcinoma. PMID: 25950810
11. EHF modifies the CF phenotype by altering capabilities of the epithelial cell to correctly process the folding and trafficking of mutant p.Phe508del-CFTR. PMID: 24105369
12. Results suggest PPAR-gamma to be involved in the regulation of ESE-3b expression during monocyte-derived dendritic cells (moDCs) development and that ESE-3 expression is not correlated with the immunogenicity of dendritic cells (DCs). PMID: 24219556
13. The SRC family tyrosine kinase HCK and the ETS family transcription factors SPIB and EHF regulate transcytosis across a human follicle-associated epithelium model. PMID: 23439650
14. ESE-3b is the functionally most important ESE-3 isoform in dendritic cells PMID: 23185370
15. Low ESE3/EHF expression was also associated with increased biochemical recurrence of prostate cancer and reduced overall survival after prostatectomy PMID: 22505649
16. EHF mRNA levels differentiate ovarian carcinoma from malignant mesothelioma. EHF may be a novel prognostic marker in ovarian carcinoma. PMID: 21855111
17. These results indicate that EHF-mediated RUVBL1 expression allows colon tumour cells to avoid p53-mediated apoptosis. PMID: 21617703
18. Overexpression of ESE-3 protein in human bronchial smooth muscle cells inhibits MMP-1 promoter activity, suggesting that ESE-3 may function as a transcriptional repressor. PMID: 12444029
19. In addition, we show the possible involvement of co-factors CBP and p300 in ESE-3-mediated DR-5 up-regulation. PMID: 17027647
20. Aberrant expression of EHF and the subsequent disruption of p27-mediated senescence and telomerase activity is likely to contribute significantly to tumor progression. EHF might be a promising target for future cancer therapeutics. PMID: 17172423
21. ESE-3 plays a role in the induction of cellular senescence as a downstream molecule of stress-induced mitogen-activated protein kinase p38. PMID: 17627613
22. Implicated as a candidate tumor suppressor in prostate cancer; decreased expression may result in loss of important regulatory mechanisms in prostate epithelial cells. PMID: 18037958
23. ESE-1 and ESE-3 play an important role in airway inflammation. PMID: 18475289

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HGNC: 3246

OMIM: 605439

KEGG: hsa:26298

STRING: 9606.ENSP00000435835

UniGene: Hs.653859